While on Facebook; side ads and info column are in center of page - can't read what's behind it.

See screen print.
Well can't post that here. . . .if you can't see it i can't explain any better. . . .on facebook there is a column to the right side that has ads, totally facebook driven. . .instead of sitting off to the right of the screen, it covers the middle of the page. . . .I've reboot ed computer, redownloaded firefox. . . .it does not do this in IE9. This just started happening today. 9/20/11.

It sounds like you may have multiple problems, but none of them are likely to be caused by malware.
First, the internet-related issues may be related to adware or a network compromise. I tend to lean more towards the latter, based on your description of the problem. See:
http://www.adwaremedic.com/kb/baddns.php
http://www.adwaremedic.com/kb/hackedrouter.php
If investigation shows that this is not a network-specific issue, then it's probably adware. See my Adware Removal Guide for help finding and removing it. Note that you mention AdBlock as if it should have prevented this, but it's important to understand that ad blockers do not protect you against adware in any way. Neither would any kind of anti-virus software, which often doesn't detect adware.
As for the other issues, it sounds like you've got some serious corruption. I would be inclined to say it sounds like a failing drive, except it sounds like you just got it replaced. How did you get all your files back after the new drive was installed?
(Fair disclosure: I may receive compensation from links to my sites, TheSafeMac.com and AdwareMedic.com, in the form of buttons allowing for donations. Donations are not required to use my site or software.)

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