Why are iTunes, View, Window, and Help menu items disabled?

I am frequently encountering an issue in iTunes 10.5 (141) where all the menu items in the iTunes, View, Window, and Help menus are disabled (greyed out). Why is this happening and can it be stopped?
I've seen this issue on different Mac OS X 10.7.2 machines. It seems to occur during playlist manipulation, where I'm making new playlists, adding items to them and editing them and the items. In the worst cases, I'm forced to quit and restart iTunes, although I have to quit by using the context menu option in the Dock as the Quit option is disabled in the application.
I'd appreciate any advice on workarounds for this that don't involve quitting and restarting iTunes.

I'm also having the same issue.  It was happening with 10.5.1 and now still with 10.5.2.  I'm using a 2008 iMac running 10.6.8.  I do not use iTunes Match.  This seems to happen for no apparent reason i/o/w, I can't determine a pattern as to when it happens, but it occurs about once in every 10 times that iTunes is open and it seems to happen after it's been open for a while, but again, no particular pattern. 
Sometimes, all the menu items are grayed out, and other times, 70% of the menu items are grayed out.  I can still use the other functionality in iTunes, but must must Quit from the dock (it quits gracefully and no Force Quit is necessary).  Relaunching restores eveything to normal for about a week. 
I work with technical diagnostic issues and can usually pinpoint a problem, isolate an issue, or determine a pattern, but this one has me stumped. I thought 10.5.2 might fix it, but no.  Maybe 10.5.3?

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