Why can't I backup my iPhone?

I have an iPhone 4S, iOS 6.0.1. I have Yosemite 10.10 with iTunes 12.0.1.26.
I want to backup and restore my phone, because I just paid my service provider to unlock it. However under file > device everything is greyed out.  How do I backup my phone?

Try this page for guidance on restoring iPhone.
Back up and restore your iPhone, iPad, or iPod touch using iCloud or iTunes - Apple Support

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