Why can't I open the adobe digital editions installer?

I've downloaded the installer, but when I click to run it, it won't open.  I click and nothing happens.

oneexwidow,
Thank you so much!!!  I tried what you said, and it worked perfectly!  I can't believe you found the answer and Adobe tech support doesn't know about this!  I think they should be aware of this issue.  I remember that file-blocking "feature" being there when looking at file properties before, but I'd forgotten about it and never thought to look there.  I've downloaded maybe hundreds of files and I don't remember having this problem before.  I knew *something* was blocking the file from running though, and I never really bought that it wasn't Vista compatible.  After all, this is the latest version and Vista is old now, since Windows 7 and now 8 have come out.  And as I mentioned, I tried it on my mom's XP computer, and it didn't run on hers either.   I'm not sure when Microsoft introduced the security feature shown above.  I hope that everyone who has this problem can find this thread so they know what to do as well.  I think Adobe should put this on the download page so everyone can see it if they have problems.
Thanks again for sharing!

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