Why distortion when output through computer out but not audio interface out?

Equipment:
Focusrite Saffire Pro 24 digital audio interface
2.5 GHz Intel Core i5 Mac Mini with 4 GB 1600 MHz DDR3
Software:
OS 10.8.2
Mainstage 2.2.2 32 bit
I'm running a mic into my digital audio interface, which connects via Firewire to my computer. The mic input is mapped to an audio channel strip. When I attempt to run sound out using the stereo out on my computer, it works okay for about 10 seconds, but then starts progressively becoming more distorted. At first, I thought it might be a bit rate issue, so I dropped it down very low. This corrected it momentarily, but, again, after about 10 seconds, the distortion came back. When I change the output to one of the audio outs on my digital audio interface though, it works fine. However, I don't have the Y cable I'd need to take 2 of the mono audio outs on that device and merge them into a stereo out that I could plug into my computer speakers (that's all I've got right now), so I'm stuck with mono out. Do you know why I'm getting this distortion on my computer's line out? I don't have audio distortion problems if I'm watching Hulu or anything, and my Saffire drivers appear to be up-to-date and Focusrite says the device is supposed to be compatible with Mountain Lion. Help is much appreciated!

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