Why do applications become "Unresponsive"?

This has been bugging me for awhile. Both on my iMac running SL and my clients G5 running Tiger, we regularly get the "Application Unresponsive" message. SL will not give me the option to quit, but rather shows the "Force Quit" message.
Adobe apps have always been a problem. Most of the time when quitting it would eventually give us the Application Unresponsive message, and then we'd have to force quit. It seems we can never just quit an Adobe app in the regular fashion.
Just now I had to force quit Aperture 3 because of the SBOD. I was also running InDesign and Photoshop. After doing some work in Photoshop I went back to Aperture and it was doing the SBOD thing.
Is this a memory issue? Or do the applications just not play well together? I've maxed the RAM on my iMac to the full 4. Or is 4 just not enough anymore? Activity Monitor didn't show anything (that I could see) unusual while it was locked up. I'm also pretty careful not to have all my apps running if I don't need them.
Do I need to restart more often? Run Yasu everyday?
Just curious.

There's no single reason for this kind of behavior. It's definitely not normal... I can easily run Photoshop Elements 8, Aperture 3 and half a dozen or more other apps (Safari, Firefox, Mail, TextWrangler, Transmit, Intaglio, etc) all at the same time and never see the problems you describe. It probably isn't memory, unless you've got some bad RAM, since I can open all those apps and have 4 GB of RAM just like you do.
You can test your RAM using [Rember|http://www.kelleycomputing.net/rember>. You should also [repair the hard drive with Disk Utility|http://support.apple.com/kb/TS1417]. Repairing permissions would probably also be a good idea. Try creating a new account on your machine and see if the problems pop up in that other account as well. Take a look at the [Mac OS X speed FAQ|http://www.index-site.com/Macosxspeed.html] in case something there helps.
As to the question on running Yasu... note that there's a reason for caches, and if you're clearing them all the time, you lose that benefit. Cache clearing should be a troubleshooting technique only, and if it doesn't help, doing it again won't help either. Take a look at [Five Mac Maintenance Myths|http://www.macworld.com/article/133684/2008/06/maintenance_intro.html].

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