Why do my audio files constantly corrupt and slip out of sync?

Whether using .caf or .aif (no MP3 audio), I get this strange issue were audio is randomly slipping out of sync.  If I use the slip tool to scrub the audio track, I can usually hear an audible digital hit in the file.  For example, I placed an explosion sound effect in the timeline and it plays back fine... then one time I'll notice the explosion is missing, but the media is still in the timeline.  Level is up.  Track is on.  If I scrub the piece of media, I may find the explosion at a later point in the audio as if copy pasted there... or I'll hear some digital hits that sound like something has been corrupted...  but at the originally intended "in" point, the explosion has simply "moved."  Happens with pieces of music,too.  I'll time something to a flourish and the flourish is missing at some point down the road and I have to do a matchframe overcut to get a new render that matches what I originally intended.  Also have to remember to copy any effects/levels and paste to the newly overcut audio.  A royal pain.
Only temporary solution has been to trash all audio renders and re-render the entire sequence.  Not a permanent fix as the problem appears again and again.  It's really frustrating (and scary) because I now no longer trust that all my audio is playing as intended without first dumping all audio render files and re-rendering.  Any ideas?
Thanks,
-A

Thanks for your reply... no, there doesn't seem to be any consistent number of frames skipped. Random pieces of audio simply simply decide to play audio from elswhere in the media.  Clicking on the waveform reveals a clear glitch of some kind... it's as if someone scrambled the media, chunks of audio in the wrong place, etc.  If I go to the original media in the bin and double-click, it plays fine.  I matchframe/overcut  re-render) and it usually fixes it, temporaririly or for good.  Sometimes I have to dump ALL renders and re-render the whole sequence.  It's driving me nuts.
I should explain that I am using up to 30 audio tracks at a time.  My machine can handle it fine, but I guess this complexity is causing problems?  The reality is, even if all audio was 48khz, there would still be a need to render because of all the layers...
I guess I should start by replacing all 44.1 khz audio with 48.1k audio and see if that fixes it...

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