Why does my entire computer freeze while opening or using After Effects or Premiere Pro CS5?

Question

Just built a computer to meet all requirements for Adobe, Autodesk 3ds Max, and UDK, for school.
Specs;
Motherboard - ASRock X79 Extreme 4-M, Socket 2011 - Micro ATX - 4 DDR3 1600/1333/1066/800 - 3 PCI-E 3.0 x 16 - 7.1 CH HD Audio - PCIE GLAN - 3 SATA3 - eSATA3 - 4 SATA2 - 4 USB 3.0 - 10 USB 2.0
Processor - Intel Core i7 Processor - i7-3820 LGA 2011
Processor fan - Intel Thermal Solution RTS2011 AC
RAM - Ballistix by Crucial - 2x  8GB Tactical PC3 - 12800 CL8 1.5 VW/XMP = 16GB RAM
SSD - Crucial M4 SSD 128GB - Comptatibility with 6Gb/s & backward compatible with SATA 3Gb/s
HDD - Seagate Barracuda 1TB - 7200 RPM up to 32mb cache
Power Supply - Cooler Master Extreme Power Plus 700W
Graphics Card - EVGA - NVIDIA GeForce GTX480 - DirectX11 - CUDA - OpenCL Support - PhysX Technology - OpenGL 4.1 (so says the box it came in; but if I'm not mistaken I think the command prompt had shown OpenGL 3 or 3.2)
Disc Driver - LG DVD/CD RW... It is an OEM, Windows claims it is updated.
I use an external component - USB Microsoft Wireless Mouse & Keyboard 2000.
I have, as far as software goes...
Windows 7 64-bit SP1
Adobe Creative Suite 5, student version or what have you.
     - I do have several plugins installed as well for After Effects only.
Autodesk 3ds Max 2012
     -I have several maxscripts as well as a couple plugins for 3ds Max.
UDK 2-2012 & 3-2012
NVIDIA PhysX Lab 1.1
NVIDIA Texture Tools 2
NVIDIA plugin for Photoshop
xNormal
ConTEXT
UnCodeX
Quicktime
AVG Free
Malwarebytes
7-Zip
Java
Sculptris
As for anything else giving me issues I haven't noticed anything besides a previous Graphics Card wasn't supported very well at all with 3ds Max, it would freeze while using the material editor which was fixed with replacing a GTX550 ti with a more compatible GTX480. Thought maybe the upgrade would also solve the fact that almost everytime I go to start up and/or use After Effects or Premiere Pro CS5 my whole system freezes. Whether or not I'm doing anything, it occasionally happened during "Scrubbing" the timeline, but also during the splash load up screen. Would take the time to wait for several minutes but nothing would change. Hard reboot was needed. After countless hours of searching online I stumbled upon what is called an "Unlock" for Premiere Pro/After Effects to allow accelerated GPU and CUDA cores. Simple procedure, seems as if things go faster... When it is working. But still, I encounter freezes on my entire system. It isn't a crash back to Windows or anytihng. Just a complete freeze on the entire system. I have not extensively used other Adobe programs besides Photoshop quite briefly just so I could open menus and force a freeze within 5 minutes and noticed nothing wrong. Which in AE & PP just running through any of the menu windows can quickly cause a sudden freeze.
note* I have alternated shutting off and turning on OpenGL as well as multiprocessing. Doesn't matter, it really doesn't seem to change much of anything.
Alas, I am absolutely sure, after checking and re-checking 80+ hours over the past 2 weeks that yes, everything is updated as far as each individual program, software or hardware will allow me to update them. I have reinstalled Windows as well as each program up to 3 times, and 1 system (restore?) I had Windows dump everything, started from scratch, backed up nothing. To reinstall everything from scratch, while not installed several "Utilities" or software components from stuff like the Motherboard and its XFAST USB/LAN or whatever, thinking maybe it was cluttering up anything.
Please, if anyone has any ideas upon this and could give me advice, whether you notice any other incompatibilities or anything. Any and all advice would be greatly appreciated. Thank you.
note* I do not have a wired Keyboard or mouse to disable the USB plugin and attempt that route.. at least not yet, its on my list of things to do. Also, I did run Memtest86+ during a boot and it claims that everything there had passed 100%. I am not "overclocking" anything either. I just wanted something I could work smoothly on, that would have decent rendering capabilities. I used to use my girls' laptop which was an HP with 3GB RAM and never experienced crashes or freezes and I could use AE, PPro, 3ds Max with some lag but not any issues. Rendering took forever on it, but I usually avoided that 'cuz it would start heating up pretty fierce. Saved my rendering for school computers where I could. But either way, now I have this expensive piece and it is getting frustrating that I cannot work on it.
note* Also, incase it does help, I have Windows as well as any major components installed onto the C: drive (aka SSD for my system) while all my secondary software, such as Adobe, Autodesk, etc. are all installed directly to my D: drive (or HDD) And everything is set up to go through Windows Firewall as well.

Answer 1

Thanks all. I have just tried a few things, installing them onto the C drive as you all specified as not being one of them. I can understand it, but at the same time i have a classmate who has their software on a seperate drive and it runs smoothe. I'm on my second GPU in 2 weeks, unless I have terrible luck it seems doubtful being that I can run games and a majority of the software no problem. Through further testing around with a corded mouse and keyboard I've noticed the following...
The computer freezes entirely only when I'm performing a "scrubbing" action or using a mouse. Left clicking, scrolling, or moving it around. Otherwise if I do not use the mouse and I make all my actions, such as "scrubbing" in AE via "Page Up & Down" keys, there's no freeze and it preloads the preview no problem.
"Scrubbing" does not load a preview (the green bar doesn't load at all while scrubbing). But, also noticed no matter how smoothe everything is running in 3ds Max as well as PPro, once I start performing a "scrubbing" action with whatever timeline I use, it will definately freeze my whole computer, Windows and all. Hard reboot is neeed.
With having gone through 2 GPU's, done a full memtest via Windows 7 and Memtest86+, there seems to be no issue with my memory or GPU. Like I said, I've run UDK without an issue. Whether the editor or game. The USB doesn't seem like it's the cause, I've used both wireless as well as wired keyboards/mouse. Still freezes, but now only when using a mouse to "Scrub".
Is it possible my motherboard could be incompatible somewhere? I mean, really.. everything is brand new but 2 weeks of troubleshooting.
And I do plan on trying to run my software off the C drive, I just wanted to make sure it wasn't something else, like I said, I've seen and used a computer where it all runs off the D drive and it runs perfectly, actually better on his computer than off the C drive at my schools. So if it is an issue would it lie within the fact that I'm using an Nvidia GPU? Considering my classmate is using a AMD/ATI Radeon or something like that.
Again, to those who replied, your shared knowledge is greatly appreciated, thank you.