Why does my keyboard and mouse freeze every time I change audio drivers?

I recently switched audio drivers from my M-Audio Ozone to my TV, which I've done before. When I tried to switch back, my mouse and keyboard become frozen! I know my Mac Mini isn't frozen, because I have my clock display the seconds and its still going strong. Help!!!

Is this your Mac:
http://www.everymac.com/systems/apple/imac/stats/imac_cd_1.83_17_ig.html
And, is this the RAM you got:
RAM Type:
PC2-5300 DDR2
Min. RAM Speed:
667 MHz
Even if it is the correct specs, it could still be a defective RAM module; also, iMacs are known to be extremely finicky about their RAM; i.e. OWC (macsales.com) and Crucial are generally recommended here - Kingston (especially their and an other Value brand line) are not. So, have you checked your RAM status? Go to Apple  in menu, click on about this Mac, click on more info, click on Memory and see that the modules show "ok" and please post back with that.
Secondly, the keyboard issue could also be a USB port issue - I had that problem on a previous (white) iMac - I kept plugging in/unplugging. The problem here is that the USB ports are an integral part of the logic board which means a rather expensive repair/replacement. So, once we've eliminated the RAM as a culprit and considering the age of the Mac, you might want to make an appointment at your nearest Genius Bar for a free evaluation and diagnosis. You can then make a decision. In my case, I was covered by Applecare, so the logic board was replaced free of charge.

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