Why is my iMac running so slowly?

Question

EtreCheck version: 1.9.12 (48)
Report generated June 17, 2014 at 7:50:21 AM EDT
Hardware Information:
          iMac (27-inch, Late 2013) (Verified)
          iMac - model: iMac14,2
          1 3.5 GHz Intel Core i7 CPU: 4 cores
          16 GB RAM
Video Information:
          NVIDIA GeForce GTX 775M - VRAM: 2048 MB
                    iMac 2560 x 1440
System Software:
          OS X 10.9.3 (13D65) - Uptime: 0 days 14:44:24
Disk Information:
          APPLE SSD SD0128F disk0 : (121.33 GB)
                    EFI (disk0s1) <not mounted>: 209.7 MB
                    disk0s2 (disk0s2) <not mounted>: 120.99 GB
                    Boot OS X (disk0s3) <not mounted>: 134.2 MB
          APPLE HDD ST1000DM003 disk1 : (1 TB)
                    EFI (disk1s1) <not mounted>: 209.7 MB
                    disk1s2 (disk1s2) <not mounted>: 999.35 GB
                    Recovery HD (disk1s3) <not mounted>: 650 MB
USB Information:
          Apple Inc. BRCM20702 Hub
                    Apple Inc. Bluetooth USB Host Controller
          Apple Inc. FaceTime HD Camera (Built-in)
Thunderbolt Information:
          Apple Inc. thunderbolt_bus
Gatekeeper:
          Anywhere
Kernel Extensions:
          [loaded] com.Cycling74.driver.SAVD (1.0.0d1 - SDK 10.6) Support
Startup Items:
          Jaksta: Path: /Library/StartupItems/Jaksta
Launch Daemons:
          [loaded] com.adobe.fpsaud.plist Support
Launch Agents:
          [running] com.rosettastone.rosettastonedaemon.plist Support
User Launch Agents:
          [running] com.akamai.single-user-client.plist Support
          [failed] com.apple.CSConfigDotMacCert-[...]@me.com-SharedServices.Agent.plist
          [running] com.genieo.completer.download.plist Support
          [loaded] com.genieo.completer.update.plist Support
          [loaded] com.nchsoftware.debut.schedule.LikeSurvey.plist Support
User Login Items:
          Wondershare Helper Compact
Internet Plug-ins:
          Flip4Mac WMV Plugin: Version: 3.2.0.16   - SDK 10.8 Support
          FlashPlayer-10.6: Version: 13.0.0.214 - SDK 10.6 Support
          iPhotoPhotocast: Version: 7.0
          Flash Player: Version: 13.0.0.214 - SDK 10.6 Outdated! Update
          Default Browser: Version: 537 - SDK 10.9
          QuickTime Plugin: Version: 7.7.3
          Google Earth Web Plug-in: Version: 7.0 Support
          Unity Web Player: Version: UnityPlayer version 4.3.7f1 - SDK 10.6 Support
          Silverlight: Version: 5.1.10411.0 - SDK 10.6 Support
          JavaAppletPlugin: Version: 14.9.0 - SDK 10.7 Check version
Safari Extensions:
          AllMyTube: Version: 4.5.0.0
Audio Plug-ins:
          BluetoothAudioPlugIn: Version: 1.0 - SDK 10.9
          AirPlay: Version: 2.0 - SDK 10.9
          AppleAVBAudio: Version: 203.2 - SDK 10.9
          iSightAudio: Version: 7.7.3 - SDK 10.9
iTunes Plug-ins:
          Quartz Composer Visualizer: Version: 1.4 - SDK 10.9
User Internet Plug-ins:
          Picasa: Version: 1.0 - SDK 10.4 Support
3rd Party Preference Panes:
          Akamai NetSession Preferences  Support
          Flash Player  Support
          Flip4Mac WMV  Support
          Tuxera NTFS  Support
Time Machine:
          Mobile backups: OFF
          Auto backup: NO - Auto backup turned off
          Volumes being backed up:
          Destinations:
                    My Passport [Local] (Last used)
                    Total size: 2 
                    Total number of backups: 10
                    Oldest backup: 2014-02-22 00:13:17 +0000
                    Last backup: 2014-02-24 01:12:40 +0000
                    Size of backup disk: Excellent
                              Backup size 2  > (Disk size 0 B X 3)
          Time Machine details may not be accurate.
          All volumes being backed up may not be listed.
Top Processes by CPU:
               2%          WindowServer
               1%          fontd
               0%          hidd
               0%          Safari
               0%          dpd
Top Processes by Memory:
          131 MB          softwareupdated
          82 MB          Finder
          66 MB          WindowServer
          66 MB          com.apple.WebKit.WebContent
          66 MB          Safari
Virtual Memory Information:
          13.24 GB          Free RAM
          1.20 GB          Active RAM
          158 MB          Inactive RAM
          1.14 GB          Wired RAM
          488 MB          Page-ins
          4 KB          Page-outs

Answer 1

Although you are here to speed up your Mac and Carolyn has probably hit on solving that for you (except that Genieo is only annoying adware and not malware), I noticed several other things that should help you out going forward.
Castle5 wrote:
Gatekeeper:
          Anywhere
There is no reason to have GateKeeper disabled. If you find the need to open an app not from the AppStore and not signed, then simply right-click / control click on the app and select Open from the popup menu. That way you will think about whether or not it's from a trusted site so you won't accidentally install Genieo Adware next time. Just make sure you use the developers web site or a reputable download site like MacUpdate. The installers at Softonic and C|Net's download.com often include unwanted add-ons.
User Launch Agents:
          [failed] com.apple.CSConfigDotMacCert-[...]@me.com-SharedServices.Agent.plist
You don't need this any more, it's left over from the old MobileMe days.
Internet Plug-ins:
          FlashPlayer-10.6: Version: 13.0.0.214 - SDK 10.6 Support
          Flash Player: Version: 13.0.0.214 - SDK 10.6 Outdated! Update
          Silverlight: Version: 5.1.10411.0 - SDK 10.6 Support
Flash Player needs a security update from System Preferences->Flash Player. Silverlight is also in need of a security related update if you use it.
User Launch Agents:
          [running] com.akamai.single-user-client.plist Support
3rd Party Preference Panes:
          Akamai NetSession Preferences  Support
Many users find that NetSessions doesn't really help, so if you continue to experience slowdowns when streaming media, consider trying with out it.
Time Machine:
          Auto backup: NO - Auto backup turned off
If you don't want to use TimeMachine, then you need to adopt some form of routine backup or chance losing any important files you have on your computer. All hard drives will fail at some point, normally around the three year point, so even though your's is relatively new, it can still fail early.