Why is my mouse making noise through my speakers?

Just got a new mac mini. I hooked it up to my M audio firewire 1814 sound card, and I'm getting noise through the speakers every time I move the mouse, every time an application is loading, every time a web page is loading. I presume it's some kind of electro magnetic interference, but does anyone know how I can remedy it? This did not happen with my previous MBP (now dead) or my borrowed Macbook.
Further detail: Through the headphone output, there is no noise. Only through the main output.
Thanks for reading

Good suggestions
Ok, just tried those things, but no luck.
I turned off wifi and BT and loaded an application, and still got a lot of noise.
I also tried...
*unplugging the screen and loading something.
*switching the power outlet I was using.
*moving the firewire cable away from all the other cables.
*switching to the second firewire port on my sound card.
More suggestions totally welcome!

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