Why is my Retina Macbook Pro slow after Yosemite

I have tried to do the Disk repairs in Safe Mode several times and then the SMC and PRAM clearing that Luis Mercado suggested in October 2014 and still have the same slow spinning wheel issue since Yosemite install.  PLEASE HELP.  BEEN A MAC GUY FOR ABOUT 7 YEARS AND LOVE MAC AND NEED IT TO WORK!!!!
EtreCheck version: 2.1.5 (108)
Report generated December 28, 2014 at 11:17:16 PM EST
Click the [Support] links for help with non-Apple products.
Click the [Details] links for more information about that line.
Click the [Adware] links for help removing adware.
Hardware Information: ℹ️
  MacBook Pro with Retina display, Intel Core i7, 15" (Mid 2012)
  MacBook Pro - model: MacBookPro10,1
  1 2.6 GHz Intel Core i7 CPU: 4-core
  8 GB RAM Not upgradeable
  BANK 0/DIMM0
  4 GB DDR3 1600 MHz ok
  BANK 1/DIMM0
  4 GB DDR3 1600 MHz ok
  Bluetooth: Good - Handoff/Airdrop2 supported
  Wireless:  en0: 802.11 a/b/g/n
Video Information: ℹ️
  Intel HD Graphics 4000
  Color LCD spdisplays_2880x1800Retina
  NVIDIA GeForce GT 650M - VRAM: 1024 MB
System Software: ℹ️
  OS X 10.10.1 (14B25) - Uptime: 2 days 12:3:50
Disk Information: ℹ️
  APPLE SSD SD512E disk0 : (500.28 GB)
  EFI (disk0s1) <not mounted> : 210 MB
  Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
  Macintosh HD (disk1) / : 499.06 GB (53.60 GB free) - 99 errors
  Encrypted AES-XTS Unlocked
  Core Storage: disk0s2 499.42 GB Online
USB Information: ℹ️
  Apple Inc. FaceTime HD Camera (Built-in)
  Apple Inc. BRCM20702 Hub
  Apple Inc. Bluetooth USB Host Controller
  Apple Inc. Apple Internal Keyboard / Trackpad
Thunderbolt Information: ℹ️
  Apple Inc. thunderbolt_bus
Gatekeeper: ℹ️
  Mac App Store and identified developers
Kernel Extensions: ℹ️
  /Applications/SyncMate.app
  [not loaded] com.eltima.SyncMate.kext (0.2.5b15) [Support]
  /Applications/Wireless Auto Import.app
  [not loaded] com.sony.driver.dsccamFirmwareUpdaterType00 (1 - SDK 10.5) [Support]
  /System/Library/Extensions
  [not loaded] com.Belcarra.iokit.USBLAN_netpart (2.0.2) [Support]
  [not loaded] com.Belcarra.iokit.USBLAN_usbpart (2.0.2) [Support]
  [not loaded] com.RemoteControl.USBLAN.usbpart (2.0.6) [Support]
  [not loaded] com.elgato.driver.DontMatchCinergyXS (1.1) [Support]
  [loaded] com.protech.NoSleep (1.3.0 - SDK 10.7) [Support]
  /System/Library/Extensions/Belcarra.USBLAN_netpart.kext/Contents/PlugIns
  [not loaded] com.belcarra.iokit.netpart.panther (1.6.1) [Support]
  /System/Library/Extensions/Belcarra.USBLAN_usbpart.kext/Contents/PlugIns
  [not loaded] com.belcarra.iokit.usbpart.panther (1.6.1) [Support]
  /System/Library/Extensions/RemoteControl.USBLAN_usbpart.kext/Contents/PlugIns
  [not loaded] com.RemoteControl.USBLAN.panther (1.6.1) [Support]
Launch Agents: ℹ️
  [loaded] com.google.keystone.agent.plist [Support]
  [running] com.sony.WirelessAutoImportLauncher.agent.plist [Support]
  [running] syncmateStarter.plist [Support]
Launch Daemons: ℹ️
  [loaded] com.adobe.fpsaud.plist [Support]
  [loaded] com.google.keystone.daemon.plist [Support]
  [loaded] com.microsoft.office.licensing.helper.plist [Support]
User Launch Agents: ℹ️
  [loaded] com.adobe.ARM.[...].plist [Support]
  [running] com.akamai.single-user-client.plist [Support]
  [running] com.microsoft.LaunchAgent.SyncServicesAgent.plist [Support]
User Login Items: ℹ️
  Microsoft Database Daemon Application (/Applications/Microsoft Office 2011/Office/Microsoft Database Daemon.app)
  IDriveMonitor UNKNOWN (missing value)
  iTunesHelper UNKNOWN (missing value)
  NoSleepHelper Application (/Applications/Utilities/NoSleepHelper.app)
  Dropbox Application (/Applications/Dropbox.app)
  AdobeResourceSynchronizer ApplicationHidden (/Applications/Adobe Reader.app/Contents/Support/AdobeResourceSynchronizer.app)
Internet Plug-ins: ℹ️
  LogitechHarmony: Version: 1.0.0.1 [Support]
  o1dbrowserplugin: Version: 5.38.6.0 - SDK 10.8 [Support]
  Google Earth Web Plug-in: Version: 6.1 [Support]
  Default Browser: Version: 600 - SDK 10.10
  Flip4Mac WMV Plugin: Version: 2.3.8.1 [Support]
  OfficeLiveBrowserPlugin: Version: 12.2.9 [Support]
  AdobePDFViewerNPAPI: Version: 11.0.10 - SDK 10.6 [Support]
  FlashPlayer-10.6: Version: 16.0.0.235 - SDK 10.6 [Support]
  DivXBrowserPlugin: Version: 1.3 [Support]
  Silverlight: Version: 5.1.20513.0 - SDK 10.6 [Support]
  Flash Player: Version: 16.0.0.235 - SDK 10.6 [Support]
  iPhotoPhotocast: Version: 7.0 - SDK 10.8
  googletalkbrowserplugin: Version: 5.38.6.0 - SDK 10.8 [Support]
  QuickTime Plugin: Version: 7.7.3
  AdobePDFViewer: Version: 11.0.10 - SDK 10.6 [Support]
  SharePointBrowserPlugin: Version: 14.4.6 - SDK 10.6 [Support]
  ContentUploaderPlugin: Version: 1.2 [Support]
  JavaAppletPlugin: Version: 15.0.0 - SDK 10.10 Check version
User internet Plug-ins: ℹ️
  fbplugin_1_0_3: Version: Unknown [Support]
  WebEx64: Version: 1.0 - SDK 10.6 [Support]
  CitrixOnlineWebDeploymentPlugin: Version: 1.0.39 [Support]
  Google Earth Web Plug-in: Version: 6.2 [Support]
Audio Plug-ins: ℹ️
  DVCPROHDAudio: Version: 1.2
3rd Party Preference Panes: ℹ️
  Akamai NetSession Preferences  [Support]
  DivX  [Support]
  Flash Player  [Support]
  Flip4Mac WMV  [Support]
  MacFUSE  [Support]
  NoSleep  [Support]
  Perian  [Support]
Time Machine: ℹ️
  Skip System Files: NO
  Mobile backups: ON
  Auto backup: YES
  Volumes being backed up:
  Macintosh HD: Disk size: 499.06 GB Disk used: 445.46 GB
  Destinations:
  Touro Backup Drive HDD [Network]
  Total size: 999.52 GB
  Total number of backups: 13
  Oldest backup: 2014-08-11 14:32:02 +0000
  Last backup: 2014-12-18 16:32:21 +0000
  Size of backup disk: Too small
  Backup size 999.52 GB < (Disk used 445.46 GB X 3)
Top Processes by CPU: ℹ️
      36% WindowServer
      20% Safari
      3% discoveryd
      1% fontd
      1% launchservicesd
Top Processes by Memory: ℹ️
  283 MB Safari
  232 MB Mail
  180 MB WindowServer
  155 MB Finder
  112 MB com.apple.WebKit.WebContent
Virtual Memory Information: ℹ️
  176 MB Free RAM
  2.78 GB Active RAM
  2.34 GB Inactive RAM
  1.64 GB Wired RAM
  6.94 GB Page-ins
  46 MB Page-outs
Diagnostics Information: ℹ️
  Dec 28, 2014, 11:07:16 PM /Library/Logs/DiagnosticReports/Preview_2014-12-28-230716_[redacted].hang
  Dec 26, 2014, 11:14:01 AM Self test - passed
  Dec 24, 2014, 05:38:53 PM /Library/Logs/DiagnosticReports/Kernel_2014-12-24-173853_[redacted].panic [Details]

The report show many hard drive errors. Did you run Disk Utiltiy from your recovery partition before upgrading the OS? Always a good action. You can run Disk Utility now while booted from your Recovery partition (press and hold command-r while booting) and see it it can repair the issues.
You hard drive is not full enough yet to cause major slowdowns but you need to keep and eye on it and make sure it does not get any more full. You have 53GB (about 10 percent) free space now. You should make sure you don't go below about 20GB. If your physical RAM fills up, Virtual Memory must find qualifying blocks on the hard drive to write swap data and, when teh drive gets crowded, VM's search process slows as does yo uoverapll performance.
You have  LOT of third-party stuff installed. "NoSleep" sounds like it could be modifying system resources; see if disabling it helps.

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    EtreCheck version: 2.1.5 (108)
    Report generated 14 January 2015 18:44:43 GMT
    Click the [Support] links for help with non-Apple products.
    Click the [Details] links for more information about that line.
    Click the [Adware] links for help removing adware.
    Hardware Information: ℹ️
      MacBook Pro (15-inch, Mid 2012) (Verified)
      MacBook Pro - model: MacBookPro9,1
      1 2.3 GHz Intel Core i7 CPU: 4-core
      4 GB RAM Upgradeable
      BANK 0/DIMM0
      2 GB DDR3 1600 MHz ok
      BANK 1/DIMM0
      2 GB DDR3 1600 MHz ok
      Bluetooth: Good - Handoff/Airdrop2 supported
      Wireless:  en1: 802.11 a/b/g/n
    Video Information: ℹ️
      Intel HD Graphics 4000
      Color LCD 1440 x 900
      NVIDIA GeForce GT 650M - VRAM: 512 MB
    System Software: ℹ️
      OS X 10.10.1 (14B25) - Uptime: 7:13:41
    Disk Information: ℹ️
      APPLE HDD HTS727575A9E362 disk0 : (750.16 GB)
      EFI (disk0s1) <not mounted> : 210 MB
      Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
      Macintosh HD (disk1) / : 748.93 GB (568.51 GB free)
      Encrypted AES-XTS Unlocked
      Core Storage: disk0s2 749.30 GB Online
      MATSHITADVD-R   UJ-8A8 
    USB Information: ℹ️
      Apple Inc. FaceTime HD Camera (Built-in)
      Apple Computer, Inc. IR Receiver
      Apple Inc. BRCM20702 Hub
      Apple Inc. Bluetooth USB Host Controller
      Apple Inc. Apple Internal Keyboard / Trackpad
    Thunderbolt Information: ℹ️
      Apple Inc. thunderbolt_bus
    Gatekeeper: ℹ️
      Mac App Store and identified developers
    Kernel Extensions: ℹ️
      /System/Library/Extensions
      [not loaded] com.devguru.driver.SamsungComposite (1.2.55 - SDK 10.6) [Support]
      /System/Library/Extensions/ssuddrv.kext/Contents/PlugIns
      [not loaded] com.devguru.driver.SamsungACMControl (1.2.55 - SDK 10.6) [Support]
      [not loaded] com.devguru.driver.SamsungACMData (1.2.55 - SDK 10.6) [Support]
      [not loaded] com.devguru.driver.SamsungMTP (1.2.55 - SDK 10.5) [Support]
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      [loaded] com.divx.dms.agent.plist [Support]
      [loaded] com.divx.update.agent.plist [Support]
      [loaded] com.oracle.java.Java-Updater.plist [Support]
      [loaded] org.macosforge.xquartz.startx.plist [Support]
    Launch Daemons: ℹ️
      [loaded] com.adobe.fpsaud.plist [Support]
      [loaded] com.oracle.java.Helper-Tool.plist [Support]
      [loaded] org.macosforge.xquartz.privileged_startx.plist [Support]
    User Launch Agents: ℹ️
      [loaded] com.adobe.ARM.[...].plist [Support]
      [loaded] com.divx.agent.postinstall.plist [Support]
      [loaded] com.facebook.videochat.[redacted].plist [Support]
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      [running] com.spotify.webhelper.plist [Support]
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      uTorrent UNKNOWN (missing value)
      KiesAgent UNKNOWNHidden (missing value)
      KiesViaWiFiAgent UNKNOWNHidden (missing value)
      Google Drive Application (/Applications/Google Drive.app)
      Google Chrome ApplicationHidden (/Applications/Google Chrome.app)
      Dropbox Application (/Applications/Dropbox.app)
      Spotify Application (/Applications/Spotify.app)
      Badoo Desktop UNKNOWN (missing value)
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      Flip4Mac WMV Plugin: Version: 3.1.0.24   - SDK 10.8 [Support]
      FlashPlayer-10.6: Version: 16.0.0.235 - SDK 10.6 [Support]
      Default Browser: Version: 600 - SDK 10.10
      AdobePDFViewerNPAPI: Version: 11.0.10 - SDK 10.6 [Support]
      AdobePDFViewer: Version: 11.0.10 - SDK 10.6 [Support]
      DivXBrowserPlugin: Version: 2.2 [Support]
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    User internet Plug-ins: ℹ️
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    Safari Extensions: ℹ️
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    Time Machine: ℹ️
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          2% Safari
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          1% WindowServer
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      60 MB Google Drive
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