Why is "Open" greyed out as an option after downloading?

My platform is Windows Vista Home Premium. My (main) browser I use is Firefox... but this problem is the same with IE (8) and Safari... all of which I have tried without success. I download a PDF attachment from my email and it downloads into my download folder. I right click on it to open and view it but the "open" and "open containing folder" options are greyed out. If I go to save the download it does not appear in the location I tell it to go to. My file associations in Windows are set correctly. I tried restoring my system but still no luck. If it has anything to do with it, this problem has surfaced when I upgraded from ver 9.0 to 9.2.

Read this article: http://support.apple.com/kb/TS1559
If that doesn't work, try restoring as new via http://support.apple.com/kb/HT4137
If that doesn't work, it's a hardwre issue.  Free replacement if within warranty and not physically damaged, $149 if it is out-of-warranty or physically damaged, no replacement if unauthorized service has been performed on the device.

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