Why is the mouse not active in system preferences?

When attempting to configure a blue tooth mouse, something happened to the wired mouse. I went to system preferences, click on mouse and got no response. Also the original colnfiguration (I'm left handed and switched buttons) appeared. The mouse works out of system preferences, but the buttons are erratic. I did a (1)reset with a simple power off using the button on the back; no change; (2) after powering off again, I upplugged the iMac for AC and removed all periperals from the computer. Then powered up again; no change. Am not willing to continue without some advice from the experts. My protection plan has expired.

Sounds weird. Have you repaired the disk permissions? Maybe USB-ports have wrong permissions in /dev.
As you cannot use mouse, open Terminal (Command - Space, type in Terminal, Enter) and type command:
diskutil repairPermissions /

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