Why won't iTunes 10.5 ... open in Safe Mode?

Have successfully performed a Selective Start of the whole PC, to discover that the iTunes freeze/ Not Responding problem persists with everything apart from Microsoft services stopped.But I can't believe Apple would really release a product which was incompatible with basic PC systems, so I'm getting really stuck ...
Anyway, one thing I've noticed in attempting to follow Apple KB advice, is that the Control + Shift method of opening iTunes in Safe Mode for diagnostic purposes, doesn't seem to work. I hold the two keys down whilst clicking on the iTunes exe shortcut ... and nothing happens.
My questions for those wiser than me:
Am I doing it right?
Assuming I am doing it right, does the failure of Safe Mode opening give any clue as to the underlying problem?
With many thanks!
David
London

I would try restarting your PC. Then attemptimg to install the latest version of iTunes and see if this helps.

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