Will I make my 2009 Mac desktop any more memory efficient by running current files, (not applications such as Indesign, Photoshop), from a portable solid-state drive? Is it worth the trouble? Thanks

I have a slightly old Mac desktop and it is starting to slow down a lot now that I am using Adobe CS6 software. It is my final year of a 5 year architecture course and I can't afford to buy a new Mac.
Some of my fellow students are having similar problems with laptops and are running applications and files from portable drives - they wiped their entire Macbooks clean. I don't want to wipe my computer and start again as I may lose some of my oldest software which I have lost CDs for. Will it make any difference to run just my active files, or even move my most memory intensive software programs, to an external drive?
My desktop has maximum RAM installed.
Any advice much appreciated.

1. OWC or Crucial are recommended sources for memory. You can usually find a 5% off and free shipping code for Crucial on retailmenot.com. On crucial just key in your system information in their memory selector.
2. Your system likely supports SATA II speeds, so the SSD OWC pointed to would work. I installed one in our 2010 mac mini and it's working well. I originally installed their 6G drive however it ran at SATA I speeds. Turns out the 3G which is specd for SATA II is what was needed and works fine.
3. The OWC package they recommended includes a case to put your existing hard drive in. That helps to be able to transfer your data back to the SSD then you can use it as a backup drive or as an external storage device.

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