Will not freeze in Safe Mode

Hi all,
My macbook pro (2008) freezes every 10 minutes or so. It has done this since I did the upgrade to 10.6.3. If started in safe mode it does not freeze, but then the speakers do not work in itunes.
Any ideas?
I have changed hard drives, reloaded OS from scratch. No joy.
John Fenn

Thanks Daddy,
I shall do a backup of "Documents" and Desktop and do a reformat and reinstall. Will keep you informed,
Great to have you guys around when we need you.
John

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