Will not open itunes on windows 7 - disk locked

I can install and uninstall itunes fine, but I can never open it due to an apparently locked disk.
I had it installed on my D drive and it was working fine, until it stopped opening one day. I recently tried installing it on my C drive, and it didn't open either. I don't know what could have caused this, except that I joined a Homegroup just before it stopped working.
Could this have anything to do with the problem? And what would be the best thing to do?

i have the same problem.  i have been downloading my cd library and some songs from my purchases at the itunes store and both will not play.  the diamond does not move.  also, my speakers are not working nor is windows media player when i try to play movie files.  not sure if they are related.  anyone find any answers?

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