Windows XP SP3 and Outlook 2010 can't connect with Exchange 2010 or Exchange 2013

XP+SP3+Outlook 2010 can't connect to Exchange 2010&2013 in the internal network without safe mode.

Hi,
Did you get any error messages?
Do you have Outlook Anywhere and autodiscovery set up properly?
Can you ping the Exchange server?
Please use Test Email AutoConfiguration
to test if the Autodiscover service is configured properly. See:
https://hosting.intermedia.net/support/kb/default.asp?id=2150
We can also use the remote connectivity analyzer to troubleshoot the issue:
https://testconnectivity.microsoft.com/
In addition, turn off your firewall and anti-virus to check the result.
Hope this helps.
Best Regards,
Steve Fan
TechNet Community Support

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