Wireless mouse/keyboard intermittent dis-connects

In the last three days, I have looked at over 20 different posts regarding wireless mouse/keyboard disconnect problems. Thew fixes ranged all over the board and NONE fixed it. And, none of these problems matched mine exactly, except for one other. I too, have two iMacs and this problem has over the last few days gotten increasingly worse and irritating. Regardless of what you're doing, whether it is actual productive work, or playing a stupid game on your computer, when your mouse quits responding, and the graphic flashed on the screen "MOUSE DISCONNECTED", it irritates.
I think a senior apple tech finally pin-pointed the problem, at least for my two systems. It has nothing at all to do with Bluetooth or Wireless networking. I tried ALL of those fixes including resetting the SMC. None fixed it.
Here is what the tech had me do. Under System Preferences > Users & Groups > My Login, I then clicked on "Login items. I was astounded to see a list that exceeded the size of the window of "startup" programs that have been installed from iTunes Helper, to Dropbox to blah, blah, blah. You name it. He had me remove ALL of them except iTunes Helper. one item "Connect service (all users) could not be removed. However, as we later discussed, the specific item the I believe to be the culprit was "Bittorrent". I've forgotten what I downloaded that used that as the download agent, but in the future, I shall NEVER AGAIN use it for ANY reason. I also removed from the applications area, some non-used programs (that probably weren't the problem, but...), emptied the trash, re-booted and have not had the problem since. I want to stress here, that if your problem is actually Bluetooth or Wireless network related, this will not fix it. However, my mouse had gotten really molassesy in that when I would try to quickly move from one spot to another on the screen, it took some time to catch up, as if something else had control. That's what I think Bittorrent or someone trying to share one of my files was causing. I don't share my files. Period. I didn't realize that it could be subverted to that use of I wouldn't have ever used it in the first place.
Anyway, neither one of my iMacs has exhibited ANY of the former symptoms since clearing that list on each system. Turns out, my second iMac also had Bittorrent in the list. That's about the only thing the two have in common besides Yosemite 10.10.3. Maybe this will help, maybe it won't. I sure hope it does. Forums like this one are extremely helpful to me.

I had the same problem... didn't find anything useful in the forums.  Just on a whim, I went to the
Control Panel | Device Manager | Universal Serial Bus Controllers
For each "Hub", right click and select "properties"
On each properties page, select "Power Management" tab
On each power management tab "uncheck" the "Allow the computer to turn off..."
I did this for the Generic USB Hubs, the USB Root Hubs, and the Reneasas...Hub.   After that was completed, all USB ports started working immediately.  So far, they are staying working but it has only been an hour or so.   Will report back if this doesn't stick.    Also, there may be a more elegant solution... but this works for now.

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