With no Firefox window open, I can't launch a new one. Or click on an email link and launch a window. This started when I upgraded to 5. Now I downgraded to 4 again and problem persists

I upgraded to Firefox 5, then noticed when a window was open I couldn't launch another one. Or launch into Firefox off an email link. Or open a new window if there was none open.
So I downgraded back to 4. Problem persists.

Uninstall the ones you know about, yes.
As regards the others, it's difficult to say. All you can do is to disable them all via Safe Mode (checkmark "Disable all add-ons", then "Make changes and restart") and then re-enable them one by one checking each time until the problem recurs. Laborious I know, but the only sound way of doing it I'm afraid.

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