Won't open existing email acounts, keeps asking to setup new account on well established system.

I have returned for a long trip (2 months) and when I start Thunderbird I can see, in the menu, the 5 accounts I have setup but with two exceptions it asks to set up a new account. The system has been working for several years but is not standard ie the different email accounts are all in different folders on a NAS server, hotmal is not but only setup as a test recently.
I have checked that the profile.ini file is there and is given below, the two profiles that works are
Fred Work (Profile 3) but is not connected to a live server as it is really an archive of my last work and the actual IMAP email is dead.
Hotmail (Profile 4) that appears full functional.
The various paths refereed to are present on the server that is still Y drive and all other file access to other programs works.
Have tried opening in offline mode.
[General]
StartWithLastProfile=0
[Profile0]
Name=Fred
IsRelative=0
Path=Y:\Data Documents\E-Mail\Fred\TBProfilesFred\zwnxsknm.default
[Profile1]
Name=Lynne
IsRelative=0
Path=Y:\Data Documents\E-Mail\Lynne\TBProfilesLynne\9fmtmx2k.default
[Profile2]
Name=Gareth
IsRelative=0
Path=Y:\Data Documents\E-Mail\Gareth\TBProfilesGareth\wx650wb9.default
[Profile3]
Name=Fred Work
IsRelative=0
Path=Y:\Data Documents\E-Mail\Fred Work
Default=1
[Profile4]
Name=Hotmail
IsRelative=1
Path=Profiles/ws270xpy.Hotmail

Have you tried doing 'get info' on the Dreamweaver application icon and checking what permissions are set? It sounds as if the application may have been set to 'system' ownership somehow with all other users and groups set to no access. If so the only way to change it is to log in as root.
http://docs.info.apple.com/article.html?artnum=106290
Disable root user afterwards and make sure you're the only one with the password.

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