Won't open files with default application

When I try to open a file it opens preview instead of the default application and does not actually open the file! I have tried changing the default application but it does not help.  How can I fix this?

Hello,
Try dragging & dropping the file on the Application's icon that you want to open it with for a test.
Safe Boot from the HD, (holding Shift key down at bootup), run Disk Utility in Applications>Utilities, then highlight your drive, click on Repair Permissions...
Reset Launch Services...
http://www.thexlab.com/faqs/resetlaunchservices.html#Anchor-Reset-47857
Reboot.

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