Worksheet takes 5-10 minutes to open/save, crashes when cells are modified

I have a worksheet with about 6 sheets of 1000 rows each. The table cells contain some references between sheets. On my MacBook Pro, it takes 5 to 10 minutes just to open the sheet. Switching between sheets in the document takes several minutes as well. When I try to edit the contents of certain columns in the sheet (the header columns), Numbers uses up 100% of the CPU for a while (sometimes hours) and then crashes.
I understand that this is a very specialized problem, and probably has to do with the worksheet itself. Is there anything I can do via this forum to help diagnose this problem and speed up Numbers behavior? I can post the document if that would help at all, or any other relevant facts about the worksheet. Just let me know what would be most helpful.
Thanks in advance,
Adrian

adrian.down wrote:
I have a worksheet with about 6 sheets of 1000 rows each. The table cells contain some references between sheets. On my MacBook Pro, it takes 5 to 10 minutes just to open the sheet. Switching between sheets in the document takes several minutes as well. When I try to edit the contents of certain columns in the sheet (the header columns), Numbers uses up 100% of the CPU for a while (sometimes hours) and then crashes.
I never got that.
I have to be patient but I never got crash in such conditions.
When I must open such document, I start by launching "Activity Monitor" so I can make the difference between Numbers heavily busy and a possible crash which I never got.
I understand that this is a very specialized problem, and probably has to do with the worksheet itself. Is there anything I can do via this forum to help diagnose this problem and speed up Numbers behavior? I can post the document if that would help at all, or any other relevant facts about the worksheet. Just let me know what would be most helpful.
I discovered recently that on PowerPC machines, Numbers make an heavy use of virtual memory (in fact, HD space) which is an efficient slowdowner.
On Intel machines, the virtual memory use is divided by about five.
You may send the file to my mailbox.
From time to time, I got files with formulas which may be optimised to get a better performance but of course, as an end user like you, I can't change what I often described as a serious design flaw.
Click my blue name to get my address.
CAUTION. Like Numbers, I'm heavily busy so I can't guarantee a fast response.
Yvan KOENIG (VALLAURIS, France) jeudi 19 août 2010 18:48:36

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Problem description:
(MacBook Pro 15” late 2008, OSX Yosemite 10.10.2 installed, no pending updates) computer is running very slow - takes 2-3 minutes to open apps such as Pages, even when no other apps are open. Randomly freezes and becomes unresponsive, requiring forced power down. Randomly logs off. Removed Kodak AIO software via Clean My Mac2, but BonjourAgent still there and requesting access. Cleaned weekly with Clean My Mac2 and running Sophos AntiVirus. 2GB memory installed. Currently 169.99 GB available of 249.2 GB capacity.
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    1 2.4 GHz Intel Core 2 Duo CPU: 2-core
    2 GB RAM Upgradeable
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