X305-q725 freezing up, but not in safe mode

Question

Yo hi you guys doing! 
I have showed up on this website a couple times now regarding my qosmio x305 Q725 for support, And I always appreciate the help from some people in this forum . So here I am AGAIN XD !!
Today (Actually yesterday) the problem I am having with my gaming laptop seems to be just as unique as the other ones (the usual). 
To sum it up, I was watching HD videos with VLC on my laptop, when the PC froze on me with a glitching and looping sound (like a CD player attempting to read a scratched cd). ctrl + alt + del wouldn't do a thing, mouse was frozen as well... Only the power off button held for a couple seconds seemed to do something useful (somewhat anyways). 
Though my laptop originally came with a 64 GB SSD with vista (32 and 64 bit) and another 320 GB D drive, I replaced both of them about 7 months ago. The new items are now: a 128 GB SSD drive with Win7 64Bit, a 500GB 7200rpm d drive.
In order to make a quick check wether or not it was the windows at fault here, I changed the C drive quickly from the 128 SSD with Win 7 back to the original 64 SSD with vista 64bit on it. Normal start up with either drives will result in another freezing and lock up laptop a couple seconds after starting it up normally, so there really is nothing to be done on that front. But when I start it in safe mode, I was able to keep it running for a good 5minutes and actually shut it off normally! 
From device manager, there was no exclamation points or irregularities (Like when my graphics card stopped functioning). The laptop seems to make the normal mechanical noises (vents, cd player, hard drives being waken up) as usual.
There you have it! Think I did not miss any points. So I guess I am wondering if this is a: Hardware problem?! though device manager won't see it... Or a software problem?! Though even my old vista exhibits the same symptoms, problem is definitely repeatable with both windows, and therefore 2 very different set of drivers (those in win7 being newer then those in the Vista drive). Maybe even a BIOS issue here?
Thanks for reading my wall of text this far , and maybe for the future help! (Using my room mate's Mac, I won't be online all the time! But I will check up asap!).
Solved!
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Answer 1

Problem's been solved for a week now, I thought I would post the solution to help other users who would use the search index.
It was a VIRUS (Actually a couple of them) which was affecting my OS most likely on the D drive (not the C drive). Though I didn't thought it could possibly be one since my Norton Antivirus 360 never picked up anything, also I changed physical C drive (Replaced the C drive from a 128GB SSD with Win7 to a 64GB SSD with vista on it which was working well the last time I used it). Completely changing C drives didn't solved the problem at all, I had no idea viruses could also be taking shelter in the D drive as well. The good people of Geek squad solved my problem quickly by analysing both hard drives with an antivirus from another computer so that the affected drives wouldn't be in use by windows directly (Hopefully I explained this right, but roughly, if your drives are in the computer, scanning for viruses may very well proove useless.... yeah !!!).
As far as they told me, if I had scanned them using another computer with an up to date antivirus in a way that the concerned drives are connected through USB, and are concidered by the computer as external devices, the antiviruses should be able to detect the threats, but not if you connected it through SATA or other "internal" device. So if you guys don't want to spend $200 at best buy I suggest you try this!
So there you go hopefully I will help other people with this explanation. I know I am not very clear in explaining it but I did my best, my knowledge is limited with computers!