Yosemite Email problems & painfully slow I Mac

Hi
I have a 2007 20 inch I Mac - 250GB  - 140GB of which is now free. It has 3GB RAM & a 2 GHz processor
I uploaded Yosemite in November - what a mistake. I managed to lose 8000 images from my i photo library (since gone into time machine to try to rebuild the library) and the whole thing has been really sluggish.
I have purchased Clean My Mac and transferred photo libraries onto hard drive as the memory was 98% full at one point.
I have followed the tips to deal with the transparency effect of the new system, altered the contrast, cleaned up the icons on my desk top and switched off stuff like spotify when it opened up
Yesterday my email stopped working. I could see the number of emails in the folder, but it would not open
I went to disc utility and checked permissions. It came up with lots & I clicked to fix them
Today - no change.
I tried to go back into time machine to restore - no change
I have about 9000 messages in there I am working through to delete (yes I know I should do better). We have multiple family accounts.
I have done a PRAM (?) safe reboot reboot - it didn't do anything
I disabled the accounts one by one. It then picked up the number of emails in one of the smaller accounts but would still not open
I have done a Cntrl R reboot and accessed disk utility
I have verified the disk
I have repaired the disc permissions
I have just done a reinstall of OS X Yosemite
It now doesn't show the number of emails at all
I have spent days on this machine trying to maintain it. It was going ok until I loaded Yosemite.
I could be cynical and think Apple have introduced new software to make the old machines obsolete earlier.
Looking for some simple and practical steps. I am not an IT whiz. It needs to be really easy to follow please
I would really appreciate some advice
thanks
Dave

Here is the report.
Mac Cleaner is still on the machine currently. I had no idea it wasn't a good thing to install.
I have filmed the sequence when I start the mail - it shows the password blocks appearing and then disappearing (almost). Not sure if I can upload here though?
Problem description:
Mail failing to open
EtreCheck version: 2.1.8 (120)
Report generated 1 February 2015 19:46:36 GMT
Download EtreCheck from http://etresoft.com/etrecheck
Click the [Click for support] links for help with non-Apple products.
Click the [Click for details] links for more information about that line.
Hardware Information: ℹ️
    iMac (20-inch, Mid 2007) (Verified)
    iMac - model: iMac7,1
    1 2 GHz Intel Core 2 Duo CPU: 2-core
    3 GB RAM Upgradeable
        BANK 0/DIMM0
            1 GB DDR2 SDRAM 667 MHz ok
        BANK 1/DIMM1
            2 GB DDR2 SDRAM 667 MHz ok
    Bluetooth: Old - Handoff/Airdrop2 not supported
    Wireless:  en1: 802.11 a/b/g/n
Video Information: ℹ️
    ATI,RadeonHD2400 - VRAM: 128 MB
        iMac 1680 x 1050
System Software: ℹ️
    OS X 10.10.2 (14C109) - Time since boot: 1:42:6
Disk Information: ℹ️
    ST3250820AS Q disk0 : (250.06 GB)
        EFI (disk0s1) <not mounted> : 210 MB
        Macintosh HD (disk0s2) / : 249.20 GB (140.36 GB free)
        Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
USB Information: ℹ️
    Apple Inc. Built-in iSight
    Apple, Inc. Keyboard Hub
        Primax Electronics Apple Optical USB Mouse
        Apple, Inc Apple Keyboard
    LaCie Porsche Desktop 4 TB
        EFI (disk1s1) <not mounted> : 315 MB
        LaCie Time Machine Back Up (disk1s2) /Volumes/LaCie Time Machine Back Up : 4.00 TB (2.56 TB free)
    Apple Computer, Inc. IR Receiver
    Apple Inc. Bluetooth USB Host Controller
Gatekeeper: ℹ️
    Mac App Store and identified developers
Kernel Extensions: ℹ️
        /System/Library/Extensions
    [loaded]    com.LaCie.ScsiType00 (1.2.8 - SDK 10.6) [Click for support]
    [not loaded]    com.jmicron.driver.jmPeripheralDevice (2.0.4) [Click for support]
    [not loaded]    com.lacie.driver.LaCie_RemoteComms (1.0.0) [Click for support]
    [not loaded]    com.oxsemi.driver.OxsemiDeviceType00 (0.09.6) [Click for support]
    [loaded]    com.rim.driver.BlackBerryUSBDriverInt (0.0.68) [Click for support]
    [not loaded]    com.rim.driver.BlackBerryUSBDriverVSP (0.0.68) [Click for support]
Launch Agents: ℹ️
    [failed]    com.adobe.CS4ServiceManager.plist [Click for support] [Click for details]
    [loaded]    com.lacie.eventsactions.launcher.agent.plist [Click for support]
    [unknown]    com.oracle.java.Java-Updater.plist [Click for support]
    [running]    com.rim.BBAlbumArtCacher.plist [Click for support]
    [running]    com.rim.BBLaunchAgent.plist [Click for support]
    [running]    com.trusteer.rapport.rapportd.plist [Click for support]
Launch Daemons: ℹ️
    [loaded]    com.adobe.fpsaud.plist [Click for support]
    [running]    com.lacie.desktopmanager.service.plist [Click for support]
    [loaded]    com.macpaw.CleanMyMac2.Agent.plist [Click for support]
    [loaded]    com.microsoft.office.licensing.helper.plist [Click for support]
    [unknown]    com.oracle.java.Helper-Tool.plist [Click for support]
    [running]    com.rim.BBDaemon.plist [Click for support]
    [running]    com.trusteer.rooks.rooksd.plist [Click for support]
    [loaded]    jp.co.canon.MasterInstaller.plist [Click for support]
User Launch Agents: ℹ️
    [loaded]    com.google.keystone.agent.plist [Click for support]
    [not loaded]    com.macpaw.CleanMyMac.helperTool.plist [Click for support]
    [not loaded]    com.macpaw.CleanMyMac.trashSizeWatcher.plist [Click for support]
    [not loaded]    com.macpaw.CleanMyMac.volumeWatcher.plist [Click for support]
    [loaded]    com.macpaw.CleanMyMac2Helper.diskSpaceWatcher.plist [Click for support]
    [loaded]    com.macpaw.CleanMyMac2Helper.scheduledScan.plist [Click for support]
    [loaded]    com.macpaw.CleanMyMac2Helper.trashWatcher.plist [Click for support]
    [running]    com.spotify.webhelper.plist [Click for support]
User Login Items: ℹ️
    WDQuickView    UNKNOWN  (missing value)
Internet Plug-ins: ℹ️
    DirectorShockwave: Version: 11.0.0r430 [Click for support]
    Scorch: Version: 6.1.0 [Click for support]
    Google Earth Web Plug-in: Version: 6.1 [Click for support]
    Default Browser: Version: 600 - SDK 10.10
    Flip4Mac WMV Plugin: Version: 2.2.0.49 [Click for support]
    Unity Web Player: Version: UnityPlayer version 2.6.1f3 [Click for support]
    Silverlight: Version: 1.0.30715 [Click for support]
    FlashPlayer-10.6: Version: 16.0.0.296 - SDK 10.6 [Click for support]
    Flash Player: Version: 16.0.0.296 - SDK 10.6 [Click for support]
    iPhotoPhotocast: Version: 7.0
    QuickTime Plugin: Version: 7.7.3
    SharePointBrowserPlugin: Version: 14.4.7 - SDK 10.6 [Click for support]
    GarminGpsControl: Version: 2.6.3.0 Release [Click for support]
    CANONiMAGEGATEWAYDL: Version: 2.1.0.1 [Click for support]
    EPPEX Plugin: Version: 10.0 [Click for support]
    CANONiMAGEGATEWAYLI: Version: 2.1.0.1 [Click for support]
    JavaAppletPlugin: Version: 15.0.0 - SDK 10.10 Check version
User internet Plug-ins: ℹ️
    RealPlayer Plugin: Version: Unknown
3rd Party Preference Panes: ℹ️
    Flash Player  [Click for support]
    Flip4Mac WMV  [Click for support]
    MacFUSE  [Click for support]
    Trusteer Endpoint Protection  [Click for support]
    YAMAHA-USBMIDIPatch  [Click for support]
Time Machine: ℹ️
    Skip System Files: NO
    Mobile backups: OFF
    Auto backup: NO - Auto backup turned off
    Volumes being backed up:
        Macintosh HD: Disk size: 249.20 GB Disk used: 108.84 GB
    Destinations:
        LaCie [Local]
        Total size: 4.00 TB
        Total number of backups: 10
        Oldest backup: 2015-01-25 12:40:55 +0000
        Last backup: 2015-02-01 11:12:55 +0000
        Size of backup disk: Excellent
            Backup size 4.00 TB > (Disk size 249.20 GB X 3)
Top Processes by CPU: ℹ️
         3%    WindowServer
         1%    launchd
         0%    AppleSpell
         0%    rapportd
         0%    BBLaunchAgent
Top Processes by Memory: ℹ️
    168 MB    Safari
    126 MB    com.apple.WebKit.WebContent
    122 MB    mds_stores
    90 MB    Mail
    71 MB    Dock
Virtual Memory Information: ℹ️
    714 MB    Free RAM
    1.42 GB    Active RAM
    627 MB    Inactive RAM
    455 MB    Wired RAM
    1.56 GB    Page-ins
    0 B    Page-outs
Diagnostics Information: ℹ️
    Feb 1, 2015, 06:02:29 PM    Self test - passed

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    Hardware Information: ℹ️
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        [not loaded]    com.kaspersky.kav.gui.plist Support
        [not loaded]    com.oracle.java.Java-Updater.plist Support
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        [invalid?]    com.valvesoftware.steamclean.plist Support
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        AdobePDFViewer: Version: 10.1.9 Support
        GarminGpsControl: Version: 2.9.3.0 Release Support
        JavaAppletPlugin: Version: Java 7 Update 71 Check version
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        Flip4Mac WMV  Support
        Growl  Support
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