Z87-G45 all USB ports stop working until I reboot

Hello everybody, This is my first post on these forums due to this problem, and I hope some people can help me out.
In February, I purchased myself a Z87-G45 motherboard along with all the other components needed to build a gaming PC, the build went brilliantly considering it was my first time!
About 3 months into my new build I started having problems with my PC, especially my USBs directly connected to the motherboard and the ones at the front of my PC as well, I have a back lit
 keyboard and mouse and the lights started flickering erratically like it was being connected and disconnected extremely quickly, then after about 10 seconds of it doing that, they both stop working.
The lights on my mouse completely go out as if it had being disconnected but the keyboards lights are still on, but none of the keys work.
 Sometimes I can do a 6 hour gaming session with my mouse or keyboard not playing up at all, but other times it happens within 5 minutes of booting up my PC!
My PSU failed at one point, and when I used a lower power PSU until my replacement came, none of these issues occurred.
 I really want to get to the bottom of this because I cannot game while my peripherals are cutting out mid game!
My specs are:
Intel Haswell i7-4770k Processor
MSI G87-G45 motherboard
Nvidia GTX 780 Graphics card
AX860 Corsair 860Watt PSU
Seagate 3TB Barracuda HDD
Sandisk 128GB SSD
16GB Vengeance Pro Black 1866MHz CL9 Memory
Windows 7

Can you download CPU-Z. Then check the Mainboard Tab in CPU-Z and check the what revision your Southbridge is.
I may be wrong but the USB disconnect after sleep was an inherent bug of the Intel C1 chipset which was corrected in C2. The initial boards all had C1.
It may be that yours is just faulty to the point that it started loosing the USB connection even though its not coming out of sleepmode.
Do check and let us know.
Quote
My PSU failed at one point, and when I used a lower power PSU until my replacement came, none of these issues occurred.
Sorry I missed this part in the initial read.
If that is the case, then it is also possible that you may have a defective PSU. The only way to confirm that is to run with another PSU for an extended period to ascertain if that is a consistent occurrence. If it doesn't happen, well then you know for sure it is PSU related. Also recheck all your connections from the PSU (especially the 24 pin connector)
Are your USB connections on the front panel or are you using the onboard USB connectors on the back?

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