Can't synchronize iPhone to computer

I've installed Leopard on all 3 of my computers. I have no problem synchronizing my wife's iPhone to my computer or my daughter's computer (thus ruling out the a problem with the iPhone itself as the cause of the problem to be described).
But I cannot get my wife's PowerBook to work well with her iPhone. When her iPhone is connected, iTunes does not automatically start up. If I start up iTunes there is a long pause and one of several things happens:
1) I get the message "iTunes could not connect to the iPhone because an unknown error occurred (0xE8000001)" or
2) After unplugging and reconnecting the iPhone I may get initial synchronizing to begin. But after copying 2 or 3 music files to the iPhone there is either a never ending beach ball or sometimes the message, "The iPhone'Your iPhone' cannot be synced. The device timed out".
Often iTunes will freeze and only a force quit will escape out of the program.
First I tried to reinstall iTunes. This didn't help. Then I did an Archive and Install. This did not help.
Any ideas? I think the iPhone is not the problem since it syncs well with my other two computers. But my wife really wants to control and sync her iPhone with her own personal computer.
Thanks.
John

I've been struggling with this problem for over a week (ever since I updated to iTunes + QT 7.5). I finally hit on the solution this morning.
*Plug the keyboard into a USB hub and the iPhone directly into the Mac.*
I've tried almost everything I could think of or found here in discussion.apple.com or other Mac sites. The partial list was: reinstall iTunes, change USB ports, connect iPhone directly without the dock, connect thru a USB hub. The iMac sees the iPhone no matter how it was connected (as confirmed in System Profiler); however, iTunes would either hang requiring a Force Quit or show a weird error message with codes like 0xE000004. Could not sync with my iMac but other computers (including a WinPC) would have the iPhone popping up in iTunes in short order.
Well, this morning I was staring at the USB list in System Profiler. I noticed that no matter which of the direct ports the iPhone was connected to (in other words, not thru the USB hub), the iPhone looked like it was connecting through the keyboard. I moved the keyboard to the hub (leaving the iPhone connected directly to the iLamp and, lo and behold, the iPhone showed up when I launched
iTunes! I immediately sync'ed, downloaded and installed the 1.1.2 update, and sync'ed again. It works!
Note that this this on an iMac 1GHz G4 with USB 1.1 ports (the "iLamp").
QS

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