Can we change the setting of Internet Explorer by Java Script?

Can we change the setting of Internet Explorer by java script?.
For e.g: I need to make the "Initialize and script control not marked as safe" as enabled by using java script code.
Please suggest me is it possible?
Thanks,
Manisha

Thanks everybody.
My requirement is to push data of a grid to Excel by clicking a button. I have written code in javascript. But if the option in Internet Explorer "Initialize and script controls not marked as safe" is disabled , i am not able to push data to Excel.
It is possible only this option is enabled.
So tried to push data by write code: document.appletname.saveAsCSVFile();
But i am not getting data in Excel in correct format.
It is coming as : first row: Column name1, " column name 2",...
                         2nd row: value1, "value2",.....
Any ideas on this?
Thanks,
manisha

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