How to design Storage Spaces with a large number of drives

I am wondering how one might go about designing a storage space for a large number of drives. Specifically I've got 45 x 4TB drives. As i am not extremely familiar with storage spaces, i'm a bit confused as to how I should go about designing this. Here is
how i would do it in hardware raid and i'd like to know how to best match this setup in Storage Spaces. I've been burned twice now by poorly designed storage spaces and i don't want to get burned again. I want to make sure if a drive fails, i'm able to properly
replace it without SS tossing it's cookies. 
In the hardware raid world, i would divide these 45 x 4TB drives into three separate 15 disk Raid 6's. (Thus losing 6 drives to parity) Each raid 6 would show up as a separate volume/drive to the parent
OS. If any disk failed in any of the three raids, i would simply pull it out and put a new disk back in and the raid would rebuild itself. 
Here is my best guess for storage spaces. I would create 3 separate storage pools each containing 15 disks. I would then create a separate
Dual Parity Virtual Disk for each pool. (Also losing 6 drives to parity) Each virtual disk would appear as a separate volume/disk
to the parent OS. Did i miss anything? 
Additionally, is there any benefit to breaking up my 45 disks into 3 separate pools? Would it be better to create one giant pool with all 45 disks and then create 3 (or however many) virtual disks on top of that one pool? 

I am wondering how one might go about designing a storage space for a large number of drives. Specifically I've got 45 x 4TB drives. As i am not extremely familiar with storage spaces, i'm a bit confused as to how I should go about designing this. Here is
how i would do it in hardware raid and i'd like to know how to best match this setup in Storage Spaces. I've been burned twice now by poorly designed storage spaces and i don't want to get burned again. I want to make sure if a drive fails, i'm able to properly
replace it without SS tossing it's cookies. 
In the hardware raid world, i would divide these 45 x 4TB drives into three separate 15 disk Raid 6's. (Thus losing 6 drives to parity) Each raid 6 would show up as a separate volume/drive to the parent
OS. If any disk failed in any of the three raids, i would simply pull it out and put a new disk back in and the raid would rebuild itself. 
Here is my best guess for storage spaces. I would create 3 separate storage pools each containing 15 disks. I would then create a separate
Dual Parity Virtual Disk for each pool. (Also losing 6 drives to parity) Each virtual disk would appear as a separate volume/disk
to the parent OS. Did i miss anything? 
Additionally, is there any benefit to breaking up my 45 disks into 3 separate pools? Would it be better to create one giant pool with all 45 disks and then create 3 (or however many) virtual disks on top of that one pool? 
1) Try to avoid parity and esp. double parity RAIDs with a typical VM workload. It's dominated by small reads (OK) and small writes (not OK as whole parity stripe gets updated with any "ready-modify-write" sequence). As a result writes would be DOG slow.
Another nasty parity RAID characteristic is very long rebuild times... It's pretty easy to get second (third with double parity) drive failure during re-build process and that would render the whole RAID set useless. Solution would be to use RAID10. Much safer,
faster to work and rebuild compared to RAID5/6 but wastes half of raw capacity...
2) Creating "islands" of storage is an extremely effective way of stealing IOPS away from your config. Typical modern RAID set would run out of IOPS long before running out of capacity so unless you're planning to have a file dump of an ice cold data or
CCTV storage you'll absolutely need all IOPS from all spindles @ the same time. This again means One Big RAID10, OBR10.
Hope this helped a bit :) Good luck!
StarWind VSAN [Virtual SAN] clusters Hyper-V without SAS, Fibre Channel, SMB 3.0 or iSCSI, uses Ethernet to mirror internally mounted SATA disks between hosts.

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