I can not open anything with out the DEP message coming on. My computer will not allow me to run Adobe Reader.

It's impossible to open any Adobe message without the program shutting down. I've tried to change the DEP but Adobe will not allow it. I can't open anything.

Try disabling Protected Mode [Edit | Preferences | Security (Enhanced)].
Note that Reader XI is not officially supported on Vista; Reader X (10.1.10) is the latest Reader version for Vista.

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