Mail boxes gone and Mail has returned to start

I opened Mail today and had problems with log on. It refused to send mail. It then froze. I did a force quit only to find that the entire application has reset to Zero i.e. no mail boxes and it asks me to set up a new account. My entire account and mailboxes has disappeared. This is a one of a series of problems following a major crash last weekend.
I then rebuilt permissions. verified the disk cleared the caches only to ind that all my prferences have been set to default. All applications are opening as if for the first time. e.g. Firefox has lost all bookmarks and my finder is at default - all dock items have disappeared as have a series of widgets. the only widgets that open are the Appe default items.

Take a look at the following articles in case there is something there that could explain what happened and post back with your observations:
Problems from insufficient RAM and free hard disk space
Recover from renaming your Home folder

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