Manage Users --Cannot Save, getting error "The resource could not be saved.... unknown error"

In Project Server 2010, in Server Settings > Manage Users we can't edit any existing users - no matter if we change something or not, as soon as we hit
the SAVE-Button, we get this error:
The resource could not be saved due to the following reasons:
An unknown error has occurred.
We have two custom Security Categories and Users Group. The Resources are synced with AD Groups every midnight. There are no Resource level Custom fields.
We were able to save it till few days, not sure what is the issue now. 
How to find out and resolve this issue!
Any hint would be of great help.
Thanks.
Greema

Hi
Go to IISManager --> Select "SharePoint Web Access" --> Double click on Compression -->
2] Uncheck both "Enable Dynamic content compression" and "Enable static content compression" --> click on Apply.
3] Do the same steps for the site where PWA is present. Then try editing the user.

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