My ipad 2 is frozen, the email system was not working so i tried to turn it off and start again but it has refused to power down

My Ipad 2 mail system was not working so i tried to power down to restart again but it has refused to power down and it also refuses to come on. i have held the power button for over a minute but there is no response.

Have you tried basics from the manual?
Restart 0- you tried.
Reset?
Restore?
iPad 2 User Guide (For iOS 4.3 Software)

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