Not able to use Adobe Reader all the time

I have a coworker who gets PDF documents in her email all the time (multi times daily). These could be POs, they could be requests, they could be most anything.
Here is the troubles ... For the last few weeks to a month she has been able to open and save as for most of the documents she gets. However, this is not the case with all the files. Some will open but not allow her to save. When she tries to go to save as, the computer freezes up on her.
I've checked all her windows updates, adobe updates, etc.This doesn't seem to help the issue any. We've uninstalled adobe reader X (which is what she had most recently with the issue), removed ALL adobe products off the computer, restarted the computer, and then re-downloaded & installed adobe X again. However, when I got back to my desk, there was a message saying that it had happened again.
Computer is running Win XP. Adobe X. All windows updates were completed as of this morning.
Any help would be greatly appreciated.
Thank you for your time and assistance.

Don't worry about the 20 questions thing ... I didn't know what else to put that would be helpful at the beginning.
As for what file(s) - it is always PDF docs, but not always the same doc, some small in size, some not so small. For example, if she opens file A, she can view/save. Then opens file B, which will not save. Go back in and file B opens/saves.
As for what program created the PDF, that I don't know.
We use Lotus Note as our email client.

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