Pop-up 'Another instance is running. Configuration system failed to initialize.'

Hello - my system kept 'freezing' when a pop-up saying, ' Silverlight Plug-in has crashed' with options to repair or close. No matter what I did, t happened several times an hour, as well as the page and pointer freezing just as frequently. Often the only solution was to turn off the computer with the on/off button. Someone at work told me to delete the plug-in and I did and the problem stopped for a few days. Now, the plug-in has reappeared on the notebook, but less frequently, and the a/n pop-up comes on when I start the notebook. I suspect this action is related to what I unsuccessfully deleted. My screen and pointer are freezing less often. I appreciate opinions on how to correct this darned annoying problem.

Hi Steve,
>>Error message is  "Configuration system failed to initialize". The popup window has the title "visual studio tools for office solution installer"
For this issue, I would recommend you try to uninstall/reinstall the VSTO runtime. The link below might be useful to you:
#Customization could not be loaded because the application domain could not be created.
https://social.msdn.microsoft.com/Forums/sharepoint/en-US/d8204b2f-d5c7-42b3-b339-d2d37d43652d/customization-could-not-be-loaded-because-the-application-domain-could-not-be-created?forum=vsto
If the method above do not work, I will recommend you install the excel add-in in the developing machine with the USB to check whether it could work correctly.  If it could not install correctly, I assume that there might be something wrong when you
publish, and could you share us the steps you published? If it works correctly, I assume that it caused by the environment of another pc, it would be helpful if you could share us the screen shoot about details error message.
Best Regards,
Edward
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    Hi Steve,
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    For this issue, I would recommend you try to uninstall/reinstall the VSTO runtime. The link below might be useful to you:
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    If the method above do not work, I will recommend you install the excel add-in in the developing machine with the USB to check whether it could work correctly.  If it could not install correctly, I assume that there might be something wrong when you
    publish, and could you share us the steps you published? If it works correctly, I assume that it caused by the environment of another pc, it would be helpful if you could share us the screen shoot about details error message.
    Best Regards,
    Edward
    We are trying to better understand customer views on social support experience, so your participation in this interview project would be greatly appreciated if you have time. Thanks for helping make community forums a great place.
    Click HERE to participate the survey.

  • Configuration system failed to initialize

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    For this issue, I would recommend you try to uninstall/reinstall the VSTO runtime. The link below might be useful to you:
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    publish, and could you share us the steps you published? If it works correctly, I assume that it caused by the environment of another pc, it would be helpful if you could share us the screen shoot about details error message.
    Best Regards,
    Edward
    We are trying to better understand customer views on social support experience, so your participation in this interview project would be greatly appreciated if you have time. Thanks for helping make community forums a great place.
    Click HERE to participate the survey.

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    Hi,
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    Thank you for your understanding.
    Best regards,
    We are trying to better understand customer views on social support experience, so your participation in this interview project would be greatly appreciated if you have time. Thanks for helping make community forums a great place.
    Click
    HERE to participate the survey.

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