After turning MacBook on, the colorful pinwheel does not stop spinning. So, I can't get into any of my Apps. I have no control. Is there a combination of keys that will give me control?

Is there a combination of keys that gives you some control of keyboard or Apps?  Opened laptop and it won't stop "thinking" and allow me to open or do anything!

You are welcome, and thank you for the courtesy of awarding the "solved" for this thread. It is not mandatory but it is certainly appreciated.
In case you are wondering, Safe Mode forces a file system check (among other things) and if it finds any issues it repairs them. Most likely that is what was causing your issue.

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