Best program for audio denoising

Hi,
I am trying to learn how to better denoise audio files. Right now I use Adobe Soundbooth, but it doesn't seem very good. Or maybe I just don't know what I'm doing!
What would you consider the best program for reducing and removing unwanted noise from audio files and recordings?

I haven't used the Isotope plug-in, but I use Brian Davies' Denoise which is a stand-alone cross-platform program: I found it much superior to SoundSoap. It's available in a free trial.
Declaration of interest: I have no financial interest in this program but was involved in the beta testing.
Together with the same author's ClickRepair it's possible to get remarkable results: this sample of a noisy 78 was treated with both programs.
http://homepage.mac.com/rfwilmut/notes/noise/companions.mp3

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