Can't open PDFs from Outlook Access denied

We are trying to open PDFs from Outlook in Reader XI.  Even after disabling protected mode, continue to receive the message "There was an error opening this document.  Access denied.".  Any suggestions?
Thanks

A. Fix One PC
Launch Adobe Acrobat Reader X
Go to: Edit > Preferences...
Click on "General" in the left pane.
Uncheck "Enable Protected Mode at startup"
You will prompted with a dialog box to remind you to close the application for the change to go into effect. Click Yes.
Click OK to save your change.
Exit Adobe Reader
B. Fix Several PCs in Your Organization
Following the above steps aren't practical if you have Adobe Acrobat installed on 1,000+ computers in 30 regional offices! Push this registry setting using your standard software deployment software.
[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\10.0\Privileged]
"bProtectedMode"=dword:00000000

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