Certain files have disappeared from my computer, certain file types remain, and the folders remain. What happened to the files, any way to get them back?

First I'll give my specs:
MacBook Pro mid-2009
Memory: 8 GB 1067 MHz DDR3
Graphics: NVIDIA GeForce 9400M 256 MB
Software: OS X 10.9.4 (13E28)
This evening I woke my computer up and the first thing I noticed was the background image had changed.
Then navigating through my folders, all files have been removed except for *some" of the following file types:
Adobe Premiere Pro, After Effects, CeltX, Final Draft, InDesign.
Files I know were there this morning and are no longer there are: PDF, MOV, TXT, and others.
When I "get info" on one of the folders that used to be populated with files, the first file size that shows is the original (i.e. 2.3 gigs) but it quickly updates to the new size of an empty folder (6 mb).
I have checked to make sure I am still logged in as the correct user, I have reset the PRAM, I have reindexed finder, I have verified and repaired the disk and verified disk permissions. I have used Terminal to show all hidden files, and none of these things have helped.
No, I do not have a backup that I can restore from. Yes, I know it is stupid.
Any insight or suggestions are welcome.
Thank you!

Try booting into the Safe Mode using your normal account. Disconnect all peripherals except those needed for the test. Shut down the computer and then power it back up after waiting 10 seconds. Immediately after hearing the startup chime, hold down the shift key and continue to hold it until the gray Apple icon and a progress bar appear. The boot up is significantly slower than normal. This will reset some caches, forces a directory check, and disables all startup and login items, among other things. When you reboot normally, the initial reboot may be slower than normal. If the system operates normally, there may be 3rd party applications which are causing a problem. Try deleting/disabling the third party applications after a restart by using the application un-installer. For each disable/delete, you will need to restart if you don't do them all at once.
Safe Mode - Mavericks
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