Cleaning out startup drive safely of Leopard machine

I have a 500G startup drive in my MacPro and Leopard on it. I want to move to SL and I also need more space for my Aperture Library. I ran WhatSize to see what was taking up so much room and have started moving photos and other nonessential stuff off....but also see that there are folders inside the Library/Application Support folder of both the main machine and user that don't seem to have utility right now = some are supporting apps no longer on my machine and some I don't know why I have them.
For instance, I have TechTool Protection folder inside Library/ApplicationSupport and it takes up 5G - if I no longer have an application on the machine can I safely delete the folder inside the Library/AppSupport folder of the machine and of the user???
I will be moving to SnowLeopard but want to address the cleaning out process first.

Within the /Home/Library/Applications Support/ folder it's safe to remove contents belonging to uninstalled applications. This is also true for the /Library/Applications Support/ folder provided you limit it to third-party applications no longer installed. However, do not start removing other files and folders from the /Library/ folder as they belong to the operating system.
If you plan to uninstall third-party applications and software then do so properly:
Uninstalling Software: The Basics
Most OS X applications are completely self-contained "packages" that can be uninstalled by simply dragging the application to the Trash. Applications may create preference files that are stored in the /Home/Library/Preferences/ folder. Although they do nothing once you delete the associated application, they do take up some disk space. If you want you can look for them in the above location and delete them, too.
Some applications may install an uninstaller program that can be used to remove the application. In some cases the uninstaller may be part of the application's installer, and is invoked by clicking on a Customize button that will appear during the install process.
Some applications may install components in the /Home/Library/Applications Support/ folder. You can also check there to see if the application has created a folder. You can also delete the folder that's in the Applications Support folder. Again, they don't do anything but take up disk space once the application is trashed.
Some applications may install a startupitem or a Log In item. Startupitems are usually installed in the /Library/StartupItems/ folder and less often in the /Home/Library/StartupItems/ folder. Log In Items are set in the Accounts preferences. Open System Preferences, click on the Accounts icon, then click on the LogIn Items tab. Locate the item in the list for the application you want to remove and click on the "-" button to delete it from the list.
Some software use startup daemons or agents that are a new feature of the OS. Look for them in /Library/LaunchAgents/ and /Library/LaunchDaemons/ or in /Home/Library/LaunchAgents/.
If an application installs any other files the best way to track them down is to do a Finder search using the application name or the developer name as the search term. Unfortunately Spotlight will not look in certain folders by default. You can modify Spotlight's behavior or use a third-party search utility, Easy Find, instead. Download Easy Find at VersionTracker or MacUpdate.
Some applications install a receipt in the /Library/Receipts/ folder. Usually with the same name as the program or the developer. The item generally has a ".pkg" extension. Be sure you also delete this item as some programs use it to determine if it's already installed.
There are also several shareware utilities that can uninstall applications:
AppZapper
CleanApp
Yank
SuperPop
Uninstaller
Spring Cleaning
Look for them at VersionTracker or MacUpdate.
For more information visit The XLab FAQs and read the FAQ on removing software.

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    Safari extensions, and perhaps the equivalent for other web browsers, are a partial exception to the above rule. Most are safe, and they're easy to get rid of if they don't work. Some may cause the browser to crash or otherwise malfunction.  Some are malicious. Use with caution, and install only well-known extensions from relatively trustworthy sources, such as the Safari Extensions Gallery.
    Never install any third-party software unless you know how to uninstall it. Otherwise you may create problems that are very hard to solve.
    4. Beware of trojans. A trojan is malicious software (“malware”) that the user is duped into installing voluntarily. Such attacks were rare on the Mac platform until sometime in 2011, but are now increasingly common, and increasingly dangerous.
    There is some built-in protection against downloading malware, but you can’t rely on it — the attackers are always at least one day ahead of the defense. You can’t rely on third-party protection either. What you can rely on is common-sense awareness — not paranoia, which only makes you more vulnerable.
    Never install software from an untrustworthy or unknown source. If in doubt, do some research. Any website that prompts you to install a “codec” or “plugin” that comes from the same site, or an unknown site, is untrustworthy. Software with a corporate brand, such as Adobe Flash Player, must be acquired directly from the developer. No intermediary is acceptable, and don’t trust links unless you know how to parse them. Any file that is automatically downloaded from a web page without your having requested it should go straight into the Trash. A website that claims you have a “virus,” or that anything else is wrong with your computer, is rogue.
    In OS X 10.7.5 or later, downloaded applications and Installer packages that have not been digitally signed by a developer registered with Apple are blocked from loading by default. The block can be overridden, but think carefully before you do so.
    Because of recurring security issues in Java, it’s best to disable it in your web browsers, if it’s installed. Few websites have Java content nowadays, so you won’t be missing much. This action is mandatory if you’re running any version of OS X older than 10.6.8 with the latest Java update. Note: Java has nothing to do with JavaScript, despite the similar names. Don't install Java unless you're sure you need it. Most people don't.
    5. Don't fill up your boot volume. A common mistake is adding more and more large files to your home folder until you start to get warnings that you're out of space, which may be followed in short order by a boot failure. This is more prone to happen on the newer Macs that come with an internal SSD instead of the traditional hard drive. The drive can be very nearly full before you become aware of the problem. While it's not true that you should or must keep any particular percentage of space free, you should monitor your storage consumption and make sure you're not in immediate danger of using it up. According to Apple documentation, you need at least 9 GB of free space on the startup volume for normal operation.
    If storage space is running low, use a tool such as the free application OmniDiskSweeper to explore your volume and find out what's taking up the most space. Move rarely-used large files to secondary storage.
    6. Relax, don’t do it. Besides the above, no routine maintenance is necessary or beneficial for the vast majority of users; specifically not “cleaning caches,” “zapping the PRAM,” "resetting the SMC," “rebuilding the directory,” "defragmenting the drive," “running periodic scripts,” “dumping logs,” "deleting temp files," “scanning for viruses,” "purging memory," "checking for bad blocks," "testing the hardware," or “repairing permissions.” Such measures are either completely pointless or are useful only for solving problems, not for prevention.
    The very height of futility is running an expensive third-party application called “Disk Warrior” when nothing is wrong, or even when something is wrong and you have backups, which you must have. Disk Warrior is a data-salvage tool, not a maintenance tool, and you will never need it if your backups are adequate. Don’t waste money on it or anything like it.

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