Hardware configuration recommendations for database and VM work

I'm looking for advice on system configuration for a computer to use at work for database, VM, and number-crunching applications. The database work will involve complex SQL queries against MySQL databases in the 5–50 GB range. I'll be using the computer for a variety of projects, and I'd like to configure and run Linux VMs on a per-project basis. The number-crunching will involve engineering applications, most of which will likely run in Linux. The database tables might be accessed from OS X or a Linux VM; I'm not sure at this point.
Advice or recommended reading on internal RAID, SAS, Fibre Channel, and the like would be appreciated. Would it make sense to have a large SATA boot drive that stores the VM and a second high-throughput drive array for the database tables? If so, what are some good options for configuring the latter? Staying in the $5k–$7k range would be nice.
Thanks,
Andreas

FileMaker is the best option if you want a good GUI front end. It's not free like MySQL but the price is worth it.

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