How much real world difference would there be between the 1600MHz memory of a 4,1 Mac Pro and the 800MHz memory of a 3,1 Mac Pro? My main app is multitrack audio with Pro Tools. Thanks so much.

How much real world performance difference would there be between the 1600MHz memory of a 4,1 Mac Pro and the 800MHz memory of a 3,1 Mac Pro? My main app is multitrack audio with Pro Tools. Thanks so much. The CPU speed of either one would be between 2.8GHz and 3.0GHz.

What are the differences.... firmware and build, there were tweaks to the PCIe bus itself. As a result 3rd party cards and booting is better.
Support in 5,1 firmware for more 56xx and W35/36xx processors. Also memory timing.
The 4,1 was "64-bit boot mode optional" and 5,1 was default. I don't know if there are changes but I assume so, even if it is not reflected elsewhere or in version number.
I don't know what the prices are but 2009, to buy one today, when the 2010 is $1800.
The 2008 of course was test bed for 64-bit UEFI and it sure seems even Lion and then ML are not as well engineered - outside of Linc who would be the least likely to have a problem.
I would assume 2010 has better support for 8GB and even 16GB DIMMs as well as for 1333MHz.
Nehalem family had only come out in fall 2008 and a lot of work went into making improvements well past 2009.
If you remember, there were serious heat problems with those and 10.5.7+ up thru 10.6.2 even with iTunes, audio, and hyperthreading and cores hitting and staying in 80*C range. That I assume was both poor code (sleep does not mean poke and ask constantly) as well as changes in SMC and kernel improvements, to work around. Microcode can be patched in firmware, kernel, by drivers and by code, but it is best when the chips and core elements don't need to be.
If someone is stretched, and can get 2009 for $1200 it might be a fine fit. That year offered the OEM GT120 which isn't really as nice and matched for today both OS and apps that rely on a GPU. And for odd reasons two such 120's don't work well in Lion+ but that is probably minor. Having the 5770 is just "nicer" though.
There are some articles about trouble booting with PCIe SATA/SAS/SSD and less trouble with 2010. Also support for graphic card and audio I think was one of those "minor" 5770 related support issues. But shows some small changes were made there too.
I wish someone would come out and pre-announce DDR4 + SATA3 along with PCIe 3.x (for bandwidth and more power per rail) along with say Ivy Bridge-E socket processors was going to be this summer's 3 yr anniversary and to replace the 2010 designed motherboard. But that is what is on Intel's and others drawing boards simmeringn in the pot.

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