How to keep track of 500+ individual patient's medications?

I'd like to build a database to alert me WHEN my patients are due to have their medication renewed.
There are perhaps 500 individual patients I need to track, and their numbers are slowly growing with time. I'd like to be able to tell who among them will need their medications renewed a few weeks ahead of time, and organize the medications shortly before they run out, if I will be on leave.
Each patient will have the same medication prescribed repeatedly over time, from once a month to once in 6 months, so the number of rows will grow in time. In 10 years time there could be 1000 patients, each with 50 or more rows.
Should I put all patients into a big spread sheet? Will the sheet grow too big to be manageable?
Or should make 500 separate little spread sheets under each person's name? In such a case, how can I check all of them in one go to find out who among them may be running out of medication within the next 30 days?
I welcome any ideas, and thank you in advance.

I can see creating this system in a flat database, a relational database, or a spreadsheet. My choice would be a relational database like FileMaker Pro because it would make daily usage easier with the downside being the design would be someone more involved. A flat database such as that provided with AppleWorks would be easy to set up and fairly easy to use - it would just require frequent sorting as you needed to switch between looking at all the prescriptions due for refilling this month and looking at a specific patient's prescription list. (You'd also need to be careful about the entry of the patient sort key - I'd recommend using a patient ID number for this rather than patient name.) Since a flat database and a spreadsheet are basically the same, the same thoughts apply.
I hesitate to recommend Numbers for this task for one major reason - database size. Just right now you are looking at a database with something between 500 and 5000 rows. If, as I suspect, you are dealing mostly with elderly patients it will be much closer to the upper number and perhaps higher. And how many fields? Patient name, ID, doctor name, phone numbers, medication name, refill date and quite a few more I suspect. And as your patient list increases...I haven't enough experience with Numbers to be confident it will handle that. Excel is another matter.
If you already own Office, I'd recommend using Excel. If you don't, think about Filemaker Pro. If the cost is beyond you or the program seems too intimidating, iList Data should be up to the task. It isn't you're only choice by any means, it is just one that I'm familiar with.

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