I get message "this ipad has not been backed up for two weeks..." It freezes on the screen, if I plug it in it does not let me shut it down and lock, it has virtually frozen my iPad, does not respond to cancel

I get a message on my wife's iPad " this iPad has nor been backed up,for two weeks, an iPad backs up when it is connected to wifi, locked, and charging". The message will not go away, hit cancel and it does nothing iPad is frozen on this screen.  Plugged it in closed cover for a few hours, still frozen, what to do?
It also says in there connects to iCloud which i left out.

Reset it by holding the power and home buttons at the same time until you see the Apple logo, then release.

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