Load report failed Access is denied ErrorCode -2147467259

Question

We've developed an ASP application with several reports that access SQL Server data.
I getting this error:
Load report failed Access is denied ErrorCode -2147467259
only on my development machine. 
I've checked every permission on every folder I can think of and I'm out of ideas. 
BTW, the reports are working just fine on the Webserver.  This problem is only occuring on my local machine.
Sandra

Answer 1

This is the line where I get the exception error
(Request.PhysicalApplicationPath & "MultiGeneral.rpt")
   'General Report
            crReportDocument = New ReportDocument
            Dim i As Integer    'TEMP
            i = crReportDocument.FileName.Length    'TEMP  
            crReportDocument.Load(Request.PhysicalApplicationPath & "MultiGeneral.rpt")
(Request.PhysicalApplicationPath & "Robots.txt")
crReportDocument.SetDatabaseLogon("intake", "password")
            If IsDBNull(Session.Item("ClientNumber")) Then
                crReportDocument.SetParameterValue("ClientNum", "")
            Else
                crReportDocument.SetParameterValue("ClientNum", Session.Item("ClientNumber"))
            End If
            If IsDBNull(Session.Item("CaseNumber")) Then
                crReportDocument.SetParameterValue("CaseNum", "")
            Else
                crReportDocument.SetParameterValue("CaseNum", Session.Item("CaseNumber"))
            End If
            crReportDocument.SetParameterValue("Followup", "0")
            crReportDocument.SetParameterValue("OrgName", "Albuquerque Metro Central Intake")
            'mfs crReportDocument.SetParameterValue("PrintCompScores", True)
            crDiskFileDestinationOptions = New DiskFileDestinationOptions
            Fname = "c:\exports\" & Session.SessionID.ToString & "_ASI1General.pdf"
            crExportOptions = crReportDocument.ExportOptions
            With crExportOptions
                .DestinationOptions = crDiskFileDestinationOptions
                .ExportDestinationType = ExportDestinationType.DiskFile
                .ExportFormatType = ExportFormatType.PortableDocFormat
            End With
            crDiskFileDestinationOptions.DiskFileName = Fname
            crReportDocument.Export()
            crReportDocument.Dispose()