Problem opening PDFs within an App-V session of Internet Explorer

I've seen similar post to this problem but no solution.
Problem is I am delivering a web based application using App-V.  This works fine except when the User tries to open PDFs.  This fails with the following error - "Adobe PDF Document" "There is a problem with Adobe Acrobat/Reader"
"If it is running, please exit and try again"
I've tried the following scenarios, all fail.
Test with Reader already open and with it not open.
LOCAL_INTERACTION_ALLOWED set to TRUE or FALSE
Windows XP or Windows 7
Sequencing with Reader 10 installed which produces a different "Visual C++ Runtime error" on Windows XP (within the sequencing Process I'm unable to open a PDF document)  Sequencer is 4.6.2.24020.
Reader Protected Mode turned Off or or Enabled (outside the App-V bubble)
Failure testing internal and external PDFs
Reader 11 makes no difference, still get the same failues.
Using ProcMon I can see AcroRd32.exe running but failing with "Access denied" error's writing to the Users's %Appdata%\Adobe folder and %temp% folders (permssions should not be an issue, User has full control).  Last Access denied failure
is "C:\Documents and Settings\%username%\Local Settings\Application Data\Adobe\Acrobat\10.0\UserCache.bin"(still fails is this is deleted or already exists)
It works fine just opening a PDF in a non-App-V IE session. I don't want to include Reader inside the IE Bubble.
Has anyone foudn a resolution to this?  Thanks in advance for help.
Shaun PDX

If you're using Reader X, have you tested with this guide from Adobe? http://www.adobe.com/devnet-docs/acrobatetk/tools/AdminGuide/appv.html
Please remember to click "Mark as Answer" or "Vote as Helpful" on the post that answers your question (or click "Unmark as Answer" if a marked post does not actually
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The Definitive Guide to Delivering Microsoft Office with App-V

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