Processing one file at a time in Biztalk

We are changing the way we're processing files in that where we used to receive hundreds of small files throughout the day, we are now going to have these files batched into larger files that get dropped to our incoming Biztalk directory. I'm concerned about
having the server pick up multiple large files at one time. Is there a way to tell a Biztalk application to only process one file at a time, and not to pick up the next file until the previous one has finished? Note, I do not have a way to build this into
the Orchestration, as this is a Biztalk application that is actually installed by our Trizetto(QNXT) product. It uses Biztalk for XML serialization. 
Thanks.

I wouldn't worry about the size of the messages unless they are approaching 1GB. BizTalk can process roughly 400 msgs/sec. Also if you're worried about processing multiple large files try load balancing. With BizTalk it is quite "easy" to load
balance. In a nut shell you have to have the dll of the application installed on all the servers you want to be apart of load balancing and BizTalk takes care of the rest. Your large files would more than likely split up and processed on different servers.
http://msdn.microsoft.com/en-us/library/aa578057(v=bts.80).aspx
The link above is for high availability but could also be used to get a better understanding of load balancing. Also if you use de-batching to split up the 3000-4000 records that would help with processing them. If an orchestration receives a file with 4000
records in them that instance alone processes the whole file. Whereas if you split up the messages each message gets it's own instance of the orchestration which leads to better performance. The only drawback is that it takes more resources so your environment
needs to be fairly large. Also if one server is busy another server with the same dll can take the de-batched messages and process them.
Here is a link to my blog post about de-batching. It is very basic but gives a good base for de-batching.
http://camartin.azurewebsites.net/post/BizTalk-Debatching

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