Users can't send/receive, but are connected to Exchange Server

Greetings,
For some reason (happened this morning), none of my users (who are a mixture of Outlook 2010 PC and Outlook 2011 Mac) can send/receive email as quickly as usual (if at all).  Exchange server is 2010.
Both clients are connected to the Exchange server successfully.  Sending an email usually takes (if it even goes at all) 10-20 minutes.  If I send an email from my Gmail account, again it take about 20 minutes to finally get to Outlook.
Exchange server is not running any virus software.  On my Outlook client for instance (2010 PC), it's stuck on Updating Inbox indefinitely.
No changes have been made to the LAN (and no other servers are having connection issues) or WAN.  I have run performance troubleshooting on the Exchange server, and all seems fine.  I have checked event viewer on both the Exchange server as well
as the DC and DNS server (they are one and the same).  I've rebooted the DC, DNS and Exchange servers.
Arrrrggggg!!  
Thanks in advance for any advice.

Hi,
According to your description, both your Exchange accounts and Gmail account have the mail delay issue.
Thus, I'd like to confirm the following information to narrow down the cause:
1. Do your external users also come across the issue? Because this may be related to Network issue.
2. Does the issue happens randomly or regularly?
And I also recommend you use Performance Monitor to check the issue as Ed said.
If you have any question, please feel free to let me know.
Thanks,
Angela Shi
TechNet Community Support

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