Unable to start Photoshop CS 6 Beta - could not open a scratch file because the file is locked (win)

The Program does nor start.
I the the following error message:
Gould not open a scratch file because the file is locked, you do not have necessary access perimssens, or another program is using the file. Use the "Properities" command In the WIndows Explorer to unlock the file.
Which file shoud  I unlock?
What means "unlock"?
Adda

"Hello, Adda. Most users can use it without problems. Did you set strict permissions on your machine?
Also, is it a small SSD? you lose their speed benefit by not putting Photoshop's scratch file on it."
Most power users are having big problems, We don't put scratch files on our SSDs because we know that this will run those into the ground. They are not intended for the pounding of constant read / write cycles. We also switch off indexing and any other constant cycling technology. Again, SSDs are best use for static files. They are, in fact, intended mainly for super fast launch, which is what they do so well. Obviously, if all you have is an SSD, then you have to live with the shortened life.
I have my scratch files and my TEMP folder set to a huge and empty internal drive. I have my USERS folder hard linked to a different huge internal drive, where I also store MY DOCUMENTS. I have an even larger internal drive where I store MY PICTURES. This has worked flawlessly (and very fast) for CS5 and LR4 Beta 1. Only CS6 complains constantly.
"Yes, I agree, but sometimes, what sounds and smells like a bug is not one, hence the troubleshooting we're trying to do, before QE tries to reproduce it."
This one not may or may not be a bug. But since I own and run dozens of applications, and only CS6 is freaking out constantly, I would say that it is not normal behavior.

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